Acetic anhydride

Guidance on Safe Use

First-aid measures

General Information

Remove contaminated, soaked clothing immediately and dispose of safely.

Inhalation

Move to fresh air. If symptoms persist, call a physician.

Skin

Wash off immediately with plenty of water. If symptoms persist, call a physician.

Eyes

Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Call a physician immediately.

Ingestion

Call a physician immediately. Do not induce vomiting without medical advice.

Note to physician:

Observe for latent pulmonary edema.

Fire-fighting measures

NFPA:

Health: 3 Flammability: 2

Instability: 1

Suitable extinguishing media

foam, dry powder, carbon dioxide (CO2)

Extinguishing media which must not be used for safety reasons

Do not use a solid water stream as it may scatter and spread fire.

Special exposure hazards arising from the substance or preparation itself, its combustion products, or released

gases

Under conditions giving incomplete combustion, hazardous gases produced may consist of

carbon monoxide

carbon dioxide (CO2)

Combustion gases of organic materials must in principle be graded as inhalation poisons

Special protective equipment for fire-fighters

self-contained breathing apparatus (EN 133).

Environmental precautions

Water run-off and vapor cloud may be corrosive. Dike and collect water used to fight fire.

Other Information

In the event of fire, cool tanks with water spray. Reacts violently with water.

Accidental release measures

Personal precautions

Avoid contact with the skin and the eyes. Keep away from heat and sources of ignition. Provide adequate ventilation.

Keep unnecessary people away; isolate hazard area and deny entry. Isolate for 800 meters or 0.5 miles in all directions if

tank, rail car, or tank truck in involved in fire. Evacuate downwind areas as conditions warrant to prevent exposure and to

allow vapors or fumes to dissipate. Spills may expose downwind areas to toxic or flammable concentrations over

considerable distances in some cases.

Environmental precautions

Prevent further leakage or spillage. Do not discharge into the drains/surface waters/groundwater.

Methods for cleaning Up

Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable, closed

containers for disposal. Dispose of in accordance with local regulations.

Authority Notification

Within the United States, call the National Response Center (800-424-8802) and appropriate state and local authorities if the

quantity released over 24 hours is equal to or greater than the reportable quantity listed below:

5000 lb/2270kg

Handling and storage

Handling

Advice on safe handling

Handle product only in closed system or provide appropriate exhaust ventilation at machinery. Store in a place

accessible by authorized persons only.

Protection - fire and explosion:

Keep away from sources of ignition - No smoking. Take necessary action to avoid static electricity discharge. In case

of fire, emergency cooling with water spray should be available.

Storage

Technical measures/Storage conditions

Keep container tightly closed in a dry and well-ventilated place.

Incompatible products

Keep away from:, bases, amines, water.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering measures

General or dilution ventilation is frequently insufficient as the sole means of controlling employee exposure. Local ventilation

is usually preferred.

Personal protective equipment

Personal protective equipment

Protective Equipment

A safety shower and eyebath should be readily available.

General advice

Use only in an area equipped with a safety shower. Avoid contact with skin and eyes. Do not breathe vapors or spray mist.

Respiratory protection

For concentrations > 1 and < 10 times the occupational exposure level: Use air-purifying respirator with full facepiece and

organic vapor cartridge(s) or air-purifying full facepiece respirator with an organic vapor canister or a full facepiece powered

air-purifying respirator fitted with organic vapor cartridge(s). The air purifying element must have an end of service life

indicator, or a documented change out schedule must be established. Otherwise, use supplied air.

For concentrations more than 10 times the occupational exposure level and less than the lower of either 100 times the

occupational exposure level or the IDLH: Use Type C full facepiece supplied-air respirator operated in positive-pressure or

continuous-flow mode.

For concentrations > 100 times the occupational exposure level or greater than the IDLH level or unknown concentrations

(such as in emergencies): Use self-contained breathing apparatus with full facepiece in positive-pressure mode or Type C

positive-pressure full facepiece supplied-air respirator with an auxiliary positive-pressure self-contained breathing apparatus

escape system.

For escape: Use self-contained breathing apparatus with full facepiece or any respirator specifically approved for escape.

Skin protection:

Wear impervious clothing and gloves to prevent contact. Butyl rubber is recommended. Other protective material may be

used, depending on the situation, if adequate degradation and permeation data is available. If other chemicals are used in

conjunction with this chemical, material selection should be based on protection for all chemicals present

Eye/face protection:

Wear chemical goggles when there is a reasonable chance of eye contact. In addition to goggles, wear a face shield if there

is a reasonable chance for splash to the face.