Benzyltriethylammonium chloride

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
1., 2. and 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Remarks:

1. The study was performed at pH range 5-9, respectively.

Duration:

5 d

Temp.:

50 °C

Remarks:

2. The study was performed at pH range 4, 7 and 9, respectively.

Temp.:

55 °C

Remarks:

3. The study was performed at pH range 5-9, respectively.

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

DT50:

> 150 - < 183 d

Remarks on result:

other: 1. at pH 5-7

pH:

9

DT50:

379 d

Remarks on result:

other: 1. Other details not known

Temp.:

50 °C

DT50:

> 5 d

Remarks on result:

other: 2. No hydrolysis was noted at any of the three levels of pH tested (i.e at pH 4, 7 and 9, respectively).

Temp.:

55 °C

DT50:

> 29 - < 146 d

Remarks on result:

other: 3. The study was performed at pH range 5-9, respectively.

Details on results:

1. The half-life value of test chemical was determined to be ranges from 150 to 183 days and 379 days at a pH range of 5-9, respectively. Thus, test chemical was reported to be hydrolytically stable under abiotic and buffered conditions over pH range 5-9, respectively.
2. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days.
3. Details not known

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 379 days, at pH range 5-9 and at a temperature of 55°C or > 5 daysat pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life value of test chemical was determinedat a pH range 5-9, respectively. The estimated half-life value of test chemical was determined to be ranges from 150 to 183 days and 379 days at a pH range of 5-9, respectively. Thus, test chemical was reported to be hydrolytically stable under abiotic and buffered conditions. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. No hydrolysis was noted at any of the three levels of pH tested and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. The half-life value of test chemical was determined to be > 5 daysat pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

For the test chemical, the half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 379 days, at pH range 5-9 and at a temperature of 55°C or > 5 daysat pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 379 days, at pH range 5-9 and at a temperature of 55°C or > 5 daysat pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

 

The half-life value of test chemical was determined at a pH range 5-9, respectively. The estimated half-life value of test chemical was determined to be ranges from 150 to 183 days and 379 days at a pH range of 5-9, respectively. Thus, test chemical was reported to be hydrolytically stable under abiotic and buffered conditions. Based on the half-life values, it is concluded that the chemical is not hydrolysable.

 

In an another study, the half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. No hydrolysis was noted at any of the three levels of pH tested and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. The half-life value of test chemical was determined to be > 5 days at pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable.

 

For the test chemical, the half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 29 days to 379 days, at pH range 5-9 and at a temperature of 55°C or > 5 days at pH 4, 7 and 9, respectively & at a temperature of 50⁰C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.