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EC number: 700-457-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50(oral) = ca. 2000 mg/kg (BASF, 2008)
LD50(dermal) > 2000 mg/kg (BASF, 2010)
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
The acute toxicity following oral administration of LIMUS-Sambaydestillation was assessed in Wistar rats in a study according to OECD 423 guideline and GLP (BASF, 2008). Single doses of 2000 and 300 mg/kg body weight of the test material preparations in doubly distilled water were given to four test groups of three fasted female animals each, (2000 mg/kg in 6 females, 300 mg/kg in 6 females) by gavage in a sequential manner. One animal of the first 2000 mg/kg test group was found dead at hour 3 after administration. Two animals of the second 2000 mg/kg test groups were found dead at hour 2 and hour 3 after administration. No mortality occurred in the 300 mg/kg test groups. Clinical observation in the 2000 mg/kg test groups revealed impaired and poor general state, dyspnoea, piloerection, exsiccosis, staggering, salivation, ataxia and reduced feces. Findings were observed from hour 0 through to study day 10 after administration. Clinical observation in the 300 mg/kg test group revealed impaired general state, dyspnoea, piloerection and reduced feces. Findings were observed from hour 0 through to study day 6 after administration. The mean body weights of the surviving animals increased normally throughout the study period. No macroscopic pathologic abnormalities were noted in the animals examined on the last day of observation (2000 mg/kg: 3 females; 300 mg/kg: 6 females). At necropsy the animals that died showed bilateral hydrothorax (ca. 2 mL), edema in all lobes of lung, dark spotted discoloration of all lobes of lung and congestion in heart, kidneys, stomach and intestine (2000 mg/kg: 3 females). Under the conditions of this study the median lethal dose of LIMUS-Sambaydestillation after oral administration was found to be ca. 2000 mg/kg body weight in rats.
Acute dermal toxicity:
In an acute dermal toxicity study (Limit Test) according to OECD 402 guideline and GLP (BASF, 2010), young adult Wistar rats (5 males and 5 females) were dermally exposed to a single dose of 2000 mg/kg bw of LIMUS Sambaydestillation (as suspension in olive oil Ph.Eur.) to the clipped skin (dorsal and dorso-Iateral parts of the trunk) and covered by semi occlusive dressing for 24 hours.
The application area comprised at least 10% of the total body surface area. The animals were observed for 14 days.
No mortality occurred. Accordingly, the acute dermal median lethal dose (LD50) in rats was determined to be > 2000 mg/kg bw.
No signs of systemic toxicity or skin effects were observed in the animals.
The mean body weight of the animals increased within the normal range throughout the study period.
No macroscopic pathologic abnormalities were noted in the animals examined at the end of the study.
Justification for classification or non-classification
Based on the available acute oral and dermal toxicity studies, the substance was classified R22 (according to Directive 67/548/EEC) and Acute toxicity oral Cat 4 (according to CLP).
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