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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP. Read-across is considered to be scientifically valid and reliability 2.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: FDA Handbook Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Trimethoxyvinylsilane
EC Number:
220-449-8
EC Name:
Trimethoxyvinylsilane
Cas Number:
2768-02-7
IUPAC Name:
trimethoxy(vinyl)silane

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
No data available.

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: none
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL

- Amount(s) applied (volume or weight with unit): 0.5ml of the test substance was applied to both the intact and abraded skin.

- Concentration (if solution): undiluted

Duration of treatment / exposure:
24 hour(s)
Observation period:
72 hours
Number of animals:
4
Details on study design:
TEST SITE

- Area of exposure: the back of the animal

- % coverage: unspecified.

- Type of wrap if used: The test areas were occluded by means of one inch gauze pads secured with adhesive tape and further occluded with a 'stockinette' sleeve covering the entire trunk of the animal.


REMOVAL OF TEST SUBSTANCE

- Washing (if done): no data, but after 24 hours the patches were removed and the resultant reactions evaluated.


SCORING SYSTEM: Draize scale.

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0
Max. score:
0
Irritant / corrosive response data:
There were no signs of erythema or edema at any time point. The Primary Irritation Index was 0.0.  The test material was a non-irritant under these conditions.
Other effects:
No other effects reported.

Any other information on results incl. tables

All values were zero at all recorded time points.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A primary irritation index value of zero was determined in a reliable skin irritation study conducted according to generally accepted scientific principles.