Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study - acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl-4-ol
EC Number:
202-179-2
EC Name:
Biphenyl-4-ol
Cas Number:
92-69-3
Molecular formula:
C12H10O
IUPAC Name:
[1,1'-biphenyl]-4-ol
Test material form:
solid: flakes

Test animals

Species:
rat
Strain:
other: SPF rats - Wistar TNO W74
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Polyethyleneglycol (Lutrol)
Doses:
5000 mg/kg
No. of animals per sex per dose:
5 males
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Criteria used for interpretation of results: EU