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Diss Factsheets
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EC number: 217-288-0 | CAS number: 1800-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
1,6–divinylfluorohexane does not contain any functional group associated with hydrolysis properties.
The molecular structure of 1,6–divinylfluorohexane is characterized by a perfluorinated carbon chain with two vinyl groups at the far ends of the molecule.
The perfluorinated carbon chain is hydrolytically stable due to the presence of the carbon-fluorine bond, which is in fact one of the strongest bonds in organic chemistry (O’Hagan, 2007). Substitution of hydrogen atoms with fluorine results in increased bond strengths for both carbon-fluorine and adjacent carbon-carbon bonds over the corresponding hydrocarbon and it is expected to increase the resistance to hydrolysis.
The terminal vinyl groups are also not expected to undergo to significant (> 10%) hydrolisis in the condition of the preliminary test described in the OECD TG No. 111 (time = 5 days, pH = 4 to 9, Temperature = 50°C). The proximity with electronegative fluorine atoms makes the vinyl ends resistant to hydrolysis both at acid and basic pHs.
Pratical experience in the use of the substance confirms its abiotic stability at pH 4 to 9 and temperature up to 50°C.
Furthermore, there is evidence of its stability in basic condition (pH>9): its synthesis, in fact, involves as the final step the treatment of its precursor in ethanol/potassium ethylate (pH>9) at 70°C: no reaction occurs on just formed 1,6–divinylfluorohexane.
In conclusion, if tested with the standard OECD TG No. 111 method, B1,6–divinylfluorohexane would not show significant hydrolysis (> 10%) in the preliminary test, meaning that conducting the full study is not justified. The substance is therefore considered hydrolytically stable and its half-life at 25°C is estimated to be > 1 year.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Understanding organofluorine chemistry. An introduction to the C–F bond
- Author:
- O'Hagan
- Year:
- 2 007
- Bibliographic source:
- Chemical Society Reviews, vol. 37, no. 2, pp. 308-319. https://doi.org/10.1039/b711844a
- Reference Type:
- publication
- Title:
- Explorations in fluorocarbon chemistry.
- Author:
- Lemal DM
- Year:
- 2 002
- Bibliographic source:
- Abstracts of papers - American Chemical Society 2002-- 223():U556-U556
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.