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EC number: 242-978-3 | CAS number: 19344-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
The acute toxicity of 3 -[(2 -hydroxyethyl)amino]propanol (CAS 19344 -29 -7) to fish was tested in a GLP-guideline study according to OECD 203 with Zebrafish (Danio rerio) as test organism. The 96 -h LC50 was determined to be > 21.5 - < 46.4 mg/L (nominal, analytically verified; BASF AG (1998); 17F0057/965014). Therefore, the substance is assessed to be acutely harmful to fish.
Long-term toxicity to fish:
No data available.
Short-term toxicity to aquatic invertebrates:
The acute toxicity to freshwater invertebrates was investigated in a GLP-test performed by BASF (1997) according to EU method C.2, using Daphnia magna as test species. In the static test the 48 -h EC50 was determined to be > 100 mg/l based on nominal test concentrations (analytically verified). The substance is concluded, to be with high probability acutely not harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates:
No data available.
Toxicity to aquatic algae and plants:
There are no reliable experimental data available. Therefore, the toxicity of the substance to algae was estimated using the QSAR model ECOSAR v1.11 of EPI Suite v4.11 (BASF SE, 2015). The substance is classified by ECOSAR as an aliphatic amine. The acute toxicity was calculated to be 425.4 mg/L (96 -h EC50). The chronic value is estimated to be 107.8 mg/L).
Based on the calculated data, the substance is concluded to be with high probability acutely not harmful to algae; in addition, chronic effects are not to be expected.
Toxicity to microorganisms:
The toxicity of 3-[(2-hydroxyethyl)amino]propanol to aquatic microorganisms was studied in an activated sludge respiration inhibition test according to OECD 209 and under the conditions of GLP. The test used activated sludge from an STP treating municipal sewage. After 180 minutes of exposure no significant effects were observed in alltest concentrations up to the highest level of 1000 mg/L. Therefore, the 180 -min EC10 was determined to be greater than 1000 mg/L (BASF SE, 2015; project no. 08G0086/15G118). Therefore, the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
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