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EC number: 236-400-9 | CAS number: 13351-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Equivalent to guideline, no GLP study, probably technical pure quality was tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dimethyl-3-phenylpropanol
- EC Number:
- 236-400-9
- EC Name:
- 2,2-dimethyl-3-phenylpropanol
- Cas Number:
- 13351-61-6
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2,2-dimethyl-3-phenylpropan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BOR: WISW
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Winkelmann, Versuchstierzucht, 4791 Borchen 1, Gartenstraße 300
- Weight at study initiation: 154-210 g (males), 145 -175 g (females)
- Fasting period before study: yes, 16 hours before test begin
- Housing: Makrolon cages III
- Diet: Ssniff, Versuchtstierdiäten GmbH, 4770 Soest/Westfalen
- Water: ad libitum, tap water
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 2
- Humidity (%): 45-55
- Photoperiod (hrs dark / hrs light): 12/12 (Fluorescent lighting)
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- peanut oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 3.5 mL/kg
DOSAGE PREPARATION: in water bath and applicated by gavage - Doses:
- 1.5, 2.0, 2.5 and 3.5 mL/kg equivalent to 1500, 2000, 2500 and 3500 mg/kg bw. (Values based on calculation with density (appx. 1 g/cm^3))
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: after 20 min, 1 h, 3 h, 24 h, 48 h, 72 h, 7 and 14 days
- Weighing: Recorded immediately before treatment (day 0) and on day 14 of postadministration.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross pathology - Statistics:
- According to probit analysis, method of Finney.
Results and discussion
- Preliminary study:
- 2 rats were tested each in doses of 15, 10, 5, 2.5 and 1.0 mL/kg
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 240 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Values based on calculation with density (appx. 1 g/cm^3)
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 730 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Values based on calculation with density (appx. 1 g/cm^3)
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 970 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Values based on calculation with density (appx. 1 g/cm^3)
- Mortality:
- Highest dose level: All animals died
2.5 mL/kg: 8 animals died
2.0 mL/kg: 6 animals died
1.5 mL/kg: 1 animal died - Clinical signs:
- other: Reduced activity, partly total apathy, partly obvious abnormal body posture, obvious disturbance of coordination, redued reflex excitability, obvious piloerection and slight decreased body temperature were noted at this dose level and above.
- Gross pathology:
- Necropsy of deceased revealed slight hemorrhages of the gastrointestinal channel. Necropsy of survivors revealed no abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The potential of the test item to cause acute oral toxicity was determined in a study equivalent to OECD 401. The LD50 (males) was determined to be 2240 mg/kg bw, the LD50 of females was determined to be 1730 mg/kg bw. The mean LD50 rats was determined to be 1970 mg/kg bw.
- Executive summary:
An acute toxicity study (equivalent to OECD guideline 401) was carried out to determine the acute oral toxicity potential of the test item. The study was conducted using albino Wistar rats weighing 154 – 210 g (males) and 145 – 175 g (females), which were acclimated for at least 7 days. Animals were group housed (5/cage) in macrolon type III cages. Fluorescent lighting, 12 hr light/12 hr dark was used in each animal room. Temperature was maintained at 21 °C and relative humidity at 45-55%. The toxicity of test compound was investigated in four groups of fasted male and female animals (5 animals/sex/dose group) at the following dose levels: 1.5, 2.0, 2.5, and 3.5 mL/kg body weight equivalent to 1500, 2000. 2500 and 3500 mg/kg bw. In each animal a number of clinical-toxicological signs were evaluated according to a modified Irwin Screening procedure. Any change from the normal condition was noted (increase or decrease) and the degree of severity of any clinical symptoms was assessed. The animals were examined at the following post-treatment intervals: 20 min, 1 h, 3 h, 24 h, 48 h, and 7 and 14 days. Body weights were recorded immediately before treatment (day 0) and on day 14 of postadministration. Animals were sacrificed after 14 days and gross pathological examinations were subsequently performed. If needed, the calculation of an oral LD50 was performed with the method of Finney.The following results were obtained:
A reduced activity, partly total apathy, partly obvious abnormal body posture, obvious disturbance of coordination, redued reflex excitability, obvious piloeretion and slight decreased body temperature were noted at this dose level and above. Necropsy of deceased revealed slight hemorrhages of the gastrointestinal channel. Necropsy of survivors revealed no abnormalities. Mortality was observed at 1500 mg/kg onwards.
The LD50 was determined to be 1970 mg/kg bw (male/females), 2240 mg/kg bw for males and 1730 mg/kg bw for females)
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