α-phenylpyridine-2-acetamide

Endpoint summary

Key value for chemical safety assessment

Effects on fertility

Description of key information

Reproductive toxicity on rat (male and female) of the target 2-phenyl-2-(pyridin-2-yl)acetamide was estimated by Leadscope QSAR probabilistic model

Toxicity to reproduction: other studies

Additional information

Leadscope FDA Model Applier prediction for reproductive toxicity on rat (both males and females) resulted to be NEGATIVE, since the positive prediction probability is equal to 0.21 (both male and females). Since at least four features were found, it was concluded that 2-phenyl-2-(pyridin-2-yl)acetamide is represented by the models. Additionally, the majority of the identified features are mainly represented in negative training compounds. The robustness of the prediction was further evaluated by examining compounds similar to the target from the training set. While this information does not take part to the prediction, it provides the complementary means to see how similar compounds are predicted and what the experimental values of similar compounds are. Only one compound from the training set of Repro Rat Male and of Repro Rat Female model was identified as analogues to 2-phenyl-2-(pyridin-2-yl)acetamide (similarity > 30%). This compound exhibit consistent negative test result for reproductive toxicity rat female but not consistent test result for reproductive toxicity rat male, being positive. Based on these considerations, Leadscope predictions for reproductive toxicity on rat males and females were assessed as borderline and moderate reliable, respectively.

	Prediction call	Prediction probability	Moderl Features count	30% Sim. Training Neighbors Count
Repro Rat Male	Negative (Borderline reliable)	0.21	6	1
Repro Rat Female	Negative (Moderate reliable)	0.21	4  (average)	1 (average)