Registration Dossier
Registration Dossier
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EC number: 262-134-8 | CAS number: 60270-33-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
28 day NOEC = 10.81 mg/L (ready biodegradation study according to EU Method C.4-C and OECD guideline 301 B, 1992, GLP, RL1)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 10.81
Additional information
The toxicity of DIMAPDO lactate (99.2% a.i.) to microorganisms was investigated during a ready biodegradation study according to EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test; 1992) and OECD guideline 301 B, 1992 over a period of 28 days and using an inoculum obtained from activated sludge of a predominantly domestic sewage treatment plant. The biodegradation rate was determined by measurement of carbon dioxide evolution.
Inoculum blank, procedural/functional control with the reference substance Sodium benzoate and a toxicity control with reference substance (10 mg C/L) and test substance (9.17 mg C/L) were performed.
The biodegradation in the toxicity control was 81% after 14 d and 100% after 28 d.
More than 25% biodegradation occurred within 14 days. Therefore, the test substance was assumed not to inhibit microbial activity at the tested concentration.
Because the study was conducted with the lactic acid salt of DIMAPDO, the 28 d NOEC based on CO2 evolution was calculated to be 10.81 mg/L in terms of DIMAPDO.
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