Registration Dossier
Registration Dossier
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EC number: 700-291-0 | CAS number: 1000701-92-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol.
- Author:
- Ballantyne and Myers
- Year:
- 1 987
- Bibliographic source:
- Vet Human Toicol 29: 361-366
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 005
- Title:
- No information
- Author:
- TSCAT, OTS0536377, Doc I.D. 88-920002325, 8ECP, 06.03.1987,|Union Carbide Corp.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexylglycol (EGHE)
- IUPAC Name:
- Hexylglycol (EGHE)
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-(hexyloxy)ethanol
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Sex:
- male/female
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 721 mg/kg bw
- Remarks on result:
- other: 0.81 ml/kgbw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 830 mg/kg bw
- Remarks on result:
- other: 0.93 ml/kgbw
- Clinical signs:
- Signs of toxicity included salivation, sluggishness, unsteady gait and comatose appearance
Applicant's summary and conclusion
- Executive summary:
Hexylglycol is the parent compound and occurs together with the sodium salt of the submission substance identity. For systemic toxicity, the glycol ether is regarded as a worst case as it is a good solvent and most probably taken up in higher percentages than the ionic salt.
Testing of this specific endpoint is additionally advised against for the submission substance because of its corrosive properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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