Registration Dossier
Registration Dossier
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EC number: 200-254-4 | CAS number: 56-06-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Test material
- Reference substance name:
- 2,6-diamino-1H-pyrimidin-4-one
- EC Number:
- 200-254-4
- EC Name:
- 2,6-diamino-1H-pyrimidin-4-one
- Cas Number:
- 56-06-4
- Molecular formula:
- C4H6N4O
- IUPAC Name:
- 2,6-diamino-1H-pyrimidin-4-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Duration of treatment / exposure:
- 4h
- Observation period:
- 72h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48,72h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: all 3 animals
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Erythema was seen in 1/3 animals at 24h, but had resolved at 48h
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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