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EC number: 203-661-5 | CAS number: 109-28-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Read-across from amides rape-oil, N-[3-(dimethylamino) propyl]:
In a 21-day semi-static toxicity test with Daphnia magna, the 21-day NOEC value and LOEC value, based on reproduction and adult length were 0.048 mg/L and 0.15 mg/L respectively. The EC10 based on reproduction was 0.07 mg/L. The EC10 based on length was 0.14 mg/L.
Key value for chemical safety assessment
Additional information
A reproduction study on aquatic
invertebrates with N-[3-(Dimethylamino)propyl]oleamide is not available.
Consequently, read-across was applied using a characteristically similar
compound, amides rape-oil, N-[3-(dimethylamino) propyl].
In oder to assess the toxicity of the test substance in an aquatic
environment, a Daphnia magna reproduction test under semi static
conditions was conducted in accordance with OECD Guideline No. 211 and
EU method C.20. Some modifications to the guideline were applied. The
test was carried out according to the bulk approach using enriched
natural surface water with a low Dissolved Organic Carbon (DOC) and
Total Suspended Solids (TSS) content, allowing a more environmentally
realistic determination of the effects of the test chemical to be made.
Young Daphnia, aged less than 24 hours, were exposed to the nominal
concentrations of 0.004, 0.015, 0.048, 0.15 and 0.5 mg test item/L over
a time period of 21 days. Primary test criterion of toxicity used was
reproductive capacity, expressed as the total number of neonates per
adult daphnid alive at the end of the test. Other endpoints based on
adult mortality, length and weight were calculated if possible.
Analytical determinations of the test solutions showed that
approximately 80% of the concentrations could be detected in the stock
solution and in the highest 3 concentrations. The recovery in the lower
concentrations fell below 80%. Loss of the chemical at lower
concentrations was considered a characteristic of the test chemical and
was accepted as part of the bulk approach. It was concluded that the
test organisms were fully exposed to the test chemical in keeping with
the bulk approach and the nominal concentrations were used for
calculations of the effect levels.
Based on the reproduction and length data of the surviving daphnia a
toxic effect could be determined. The NOEC value and LOEC value, based
on reproduction and adult length were 0.048 mg/L and 0.15 mg/L
respectively. The EC10 based on reproduction was calculated as 0.07 mg/L
(confidence limits could not be calculated). The EC10 based on length
was calculated as 0.14 mg/L (confidence limits could not be calculated).
The dry weight endpoints was considered unreliable due to the inaccuracy
involved in weighing the low number of surviving daphnids. The adult
mortality endpoint was not considered reliable due to physical effects
being the most likely cause of the effects.
The following validity criteria were fulfilled:
Mortality in the control did not exceed 20% during the test period.
The average number of juveniles per parent in the control was 61.
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