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EC number: 247-104-4 | CAS number: 25564-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline. Limited information (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The test material and appropriate standards are applied to the clipped dorsum of rabbits for 4 hours under individual semi-occlusive patches. After removal of the patches, the treated areas are wiped and examined for evidence of irritation. Further assessments are made 24, 48 and 72 hours after treatments, and occasioanlly up to 7 days after treatment.
- GLP compliance:
- no
- Remarks:
- This study pre-dates the introduction of GLP in the UK
Test material
- Reference substance name:
- 2-pentylcyclopent-2-enone
- IUPAC Name:
- 2-pentylcyclopent-2-enone
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- 8 new Zealand White rabbits, aged 9-12 weeks are used for each test. The whole dorsal surface is clipped 3-4 days before the test is due to start, and animals in the telogen phase of hair growth are selected.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml of test solution is applied to a dry patch
- Duration of treatment / exposure:
- Up to 72 hours.
- Observation period:
- Up to 72 hours
- Number of animals:
- 8 new Zealand White rabbits
- Details on study design:
- Scoring System:
Treatment sites weree assessed for erythema, oedema, cracking, scaling dryness, haemorage, ulceration, scabbing and exudation on a 8-point scale.
1 - marginal/very slight; 2 = slight; 3 = fairly distincy; 4 = quite distinct; 6 = becoming well developed; 8 = well developed; 10 = becoming severe; 12 = severe.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.75
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 4.5
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.25
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 2.75
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.25
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.25
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.25
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.75
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 4
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.25
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal: #7
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 2.75
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal: #7
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 5
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal: #8
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 2.5
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal: #8
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 2.5
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.19
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings
- Score:
- 3.53
- Max. score:
- 12
- Reversibility:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Mean of 4, 24, 48 and 72 hour gradings per Site per Day
- Score:
- 7.16
- Max. score:
- 12
- Reversibility:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: description of scoring system in study report
- Conclusions:
- An application (0.5 mL) of undiluted Pentyl Cyclopentenone FAB (2-Pentylcyclopent-2-enone) was found to be moderately irritating to the skin of rabbits.
- Executive summary:
In an in vivo study, conducted prior to the introduction of GLP or the applicable OECD test guideline, undiluted Pentyl Cyclopentenone FAB (2-Pentylcyclopent-2-enone, 0.5 mL) was applied to the skin of 8 New Zealand White rabbits.
Mean erytherma and oedema scores of 3.19 and 3.53 (out of 12) were reported for the treated group, expressed as a mean of the 4, 24, 48 and 72 hour gradings. According to the scoring system in the report, this represented a moderate irritant. Other effects reported included cracking ( mean score 1.63/12) and scaling (0.125/12) of the skin. Reversiblity effects not fully assessed.
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