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Diss Factsheets
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EC number: 942-925-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP condition
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Azo zinc complex Pigment - Melamine compound
- IUPAC Name:
- Azo zinc complex Pigment - Melamine compound
- Test material form:
- other: brown powder
- Details on test material:
- Molecular weight 615.79
Lot no.BOS 3479-3423
purity/content: 100 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 7 weeks
- Weight at study initiation: males,206.6 g-215.0 g; females 209.7 g-229.2 g
- Fasting period before study: no data
- Housing: individually
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 50
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on dermal exposure:
- The test substance was applied uniformly over an area which was approximately 10% of the total body surface area. Test substance were held in contact with the skin with a porous gauze dresssing and non-irritating tape throughout the 24-hour exposure period.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- The test substance (2000 mg/kg bw) was applied uniformly over an area which was approximately 10% of the total body surface area. Test substance were held in contact with the skin with a porous gauze dresssing and non-irritating tape throughout the 24-hour exposure period. The wrappings were removed at 24 hours after applicatiopn. the applied areas were washed out gently with distilled water. the animals were observed for clinical signs and mortality and changes of body weight over a period of 14 days.
- Statistics:
- statistical analysis were performed by comparing the treatment group and the control group. Variance of numerical data was checked by F-test; then the student t-test was conducted to determine the singnificant difference between two groups
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: no clinical signs, no mortality, body weight gain, no findings at necropsy
- Mortality:
- No death occurred in all animals during the experimental period
- Clinical signs:
- clinical signs related with the substance wer not observed in any amimals during the observation period
- Body weight:
- all living animals showed the normal increase in body weight
- Gross pathology:
- In all animals there were no lesons caused by administration of test substance
Applicant's summary and conclusion
- Executive summary:
Acute dermal toxicity was examined in male and female Sprague-Dawley rats in accordance with OECD TG 402 under GLP conditions.The test substance (2000 mg/kg bw) was applied uniformly over an area which was approximately 10% of the total body surface area. Test substance were held in contact with the skin with a porous gauze dresssing and non-irritating tape throughout the 24-hour exposure period. The wrappings were removed at 24 hours after applicatiopn. the applied areas were washed out gently with distilled water. the animals were observed for clinical signs and mortality and changes of body weight over a period of 14 days.
No mortality was observed in the present study. Clinical signs related with the substance were not observed in any animal during the observaion period. All tested animals showed normal gains in body weight. In all animals there were no necropsy findings caused by administration of test substance.
Based on these results the LD50 value was considered to be higher than 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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