1,6-Naphthyridine-3-carboxylic acid, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-, 2-cyanoethyl ester

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

not applicable

GLP compliance:

no

Type of method:

thermal analysis

Remarks:

Differential Thermal Analysis (DTA)

Key result

Melting / freezing pt.:

195.7 °C

Remarks on result:

other: atmospheric pressure assumed

Between approx. 180–210 °C an endothermic phase could be detected which indicates the melting point of the test item. Due to the off-white and yellow-orange residues in the crucible after the melting process a transition or decomposition of the test item while melting is possible.

The melting temperature of the test item lies at 195.7 °C (mean of four determinations, twice in an open and twice in a closed crucible).

Conclusions:

CN-ethyl-TH-naphthyridin has a melting point at 195.7 °C. Due to the off-white and yellow-orange residues in the crucible after the melting process a transition or decomposition of the test item while melting is possible.

Executive summary:

The melting point of CN-ethyl-TH-naphthyridin was determined according to EU Method A.1 by differential thermoanalysis method (DTA). The sample was weighed in a crucible made of aluminum, cooled down in a DTA/DSAC-system to 25 °C and then heated up to 450 °C (heating rate 5 K/min). In comparison with an inert sample (empty crucible) the temperature difference and the heat effect was recorded. Between approx. 180–210 °C an endothermic phase could be detected which indicates the melting point of the test item. CN-ethyl-TH-naphthyridin has a melting point at 195.7 °C (mean of four determinations, twice in an open and twice in a closed crucible). A second heating could not reproduce the melting point which indicates a chemical transformation of the test item. This assumption is supported by the yellow (open crucible) and by the light orange (closed crucible) melt in the crucible. The sample was heated up to 220 °C, cooled down to 180 °C and heated up again.

Description of key information

CN-ethyl-TH-naphthyridin has a melting point at 195.7 °C. Due to the off-white and yellow-orange residues in the crucible after the melting process a transition or decomposition of the test item while melting is possible. No pressure was reported.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

195.7 °C