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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
Experimental Carcinogenicity and Acute Toxicity of Representative Epoxides
Author:
Weil, C.S., Condra, N., Haun, C. and Striegel, J.A.
Year:
1963
Bibliographic source:
American Industrial Hygiene Assocociation Journal, 24(4), 305-324

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Skin irritation study using less test material than current guidelines require
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
EC Number:
500-033-5
EC Name:
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
Cas Number:
25068-38-6
Molecular formula:
(C15H16O2 . C3H5ClO)x
IUPAC Name:
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
Test material form:
liquid: viscous

Test animals

Species:
rabbit
Strain:
other: clipped fur

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
Observations of skin were performed after 1, 24, 48 and 72 hours as well as 7 days since the end of exposure.
Number of animals:
5
Details on study design:
Primary dermal irritation on rabbits was recorded according to a 10-grade ordinal series and was based upon the most severe reaction that developed. The skin of each of 5 rabbits was clipped within 24 hours of the uncovered application of 0.01mL of undiluted sample or of solutions in water, propylene glycol, or acetone. Grade 1 indicated no irritation, Grade 6 was necrosis when undiluted, and Grade 10 was necrosis with a 0.01% solution.

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 hr
Score:
ca. 1
Max. score:
10
Reversibility:
no data
Irritant / corrosive response data:
Results were reported as a Grade 1 on the 10-grade scale used by the investigators.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: PDI index
Conclusions:
Not irritating- Results were reported as a Grade 1 on the 10-grade scale used by the investigators.
Executive summary:

Test material, 0.01 ml, was applied to the skin of rabbits for 24 hours. After the 24 hour exposure period, there was no irritation observed and thus the test material was considered non-irritating.