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EC number: 500-213-3 | CAS number: 68439-50-9 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 16 - 31 May 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 1981
- Deviations:
- yes
- Remarks:
- occlusive dressing
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 2015
- Deviations:
- yes
- Remarks:
- no sequential testing approach; occlusive dressing
- GLP compliance:
- no
Test material
- Reference substance name:
- Dodecan-1-ol
- EC Number:
- 203-982-0
- EC Name:
- Dodecan-1-ol
- Cas Number:
- 112-53-8
- Molecular formula:
- C12H26O
- IUPAC Name:
- Dodecan-1-ol
- Reference substance name:
- 2-(dodecyloxy)ethanol
- EC Number:
- 224-886-5
- EC Name:
- 2-(dodecyloxy)ethanol
- Cas Number:
- 4536-30-5
- Molecular formula:
- C14H30O2
- IUPAC Name:
- 2-(dodecyloxy)ethanol
- Reference substance name:
- 2-[2-(dodecyloxy)ethoxy]ethanol
- EC Number:
- 221-279-7
- EC Name:
- 2-[2-(dodecyloxy)ethoxy]ethanol
- Cas Number:
- 3055-93-4
- Molecular formula:
- C16H34O3
- IUPAC Name:
- 2-[2-(dodecyloxy)ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethanol
- EC Number:
- 221-280-2
- EC Name:
- 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethanol
- Cas Number:
- 3055-94-5
- Molecular formula:
- C18H38O4
- IUPAC Name:
- 2-{2-[2-(dodecyloxy)ethoxy]ethoxy}ethanol
- Reference substance name:
- 3,6,9,12-tetraoxatetracosan-1-ol
- EC Number:
- 226-097-1
- EC Name:
- 3,6,9,12-tetraoxatetracosan-1-ol
- Cas Number:
- 5274-68-0
- Molecular formula:
- C20H42O5
- IUPAC Name:
- 3,6,9,12-tetraoxatetracosan-1-ol
- Reference substance name:
- 3,6,9,12,15-pentaoxaheptacosan-1-ol
- EC Number:
- 221-281-8
- EC Name:
- 3,6,9,12,15-pentaoxaheptacosan-1-ol
- Cas Number:
- 3055-95-6
- Molecular formula:
- C22H46O6
- IUPAC Name:
- 2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
- Reference substance name:
- 3,6,9,12,15,18-hexaoxatriacontan-1-ol
- EC Number:
- 221-282-3
- EC Name:
- 3,6,9,12,15,18-hexaoxatriacontan-1-ol
- Cas Number:
- 3055-96-7
- Molecular formula:
- C24H50O7
- IUPAC Name:
- 2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- Reference substance name:
- 3,6,9,12,15,18,21-heptaoxatritriacontanol
- EC Number:
- 221-283-9
- EC Name:
- 3,6,9,12,15,18,21-heptaoxatritriacontanol
- Cas Number:
- 3055-97-8
- Molecular formula:
- C26H54O8
- IUPAC Name:
- 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- Reference substance name:
- Tetradecanol
- EC Number:
- 204-000-3
- EC Name:
- Tetradecanol
- Cas Number:
- 112-72-1
- Molecular formula:
- C14H30O
- IUPAC Name:
- tetradecan-1-ol
- Reference substance name:
- 2-(tetradecyloxy)ethanol
- EC Number:
- 218-371-4
- EC Name:
- 2-(tetradecyloxy)ethanol
- Cas Number:
- 2136-70-1
- Molecular formula:
- C16H34O2
- IUPAC Name:
- 2-(tetradecyloxy)ethanol
- Reference substance name:
- 2-(2-Tetradecyloxyethoxy)ethanol
- EC Number:
- 611-348-3
- Cas Number:
- 56049-79-7
- Molecular formula:
- C18H38O3
- IUPAC Name:
- 2-(2-Tetradecyloxyethoxy)ethanol
- Reference substance name:
- 2-[2-[2-(tetradecyloxy)ethoxy]ethoxy]ethanol
- EC Number:
- 248-016-9
- EC Name:
- 2-[2-[2-(tetradecyloxy)ethoxy]ethoxy]ethanol
- Cas Number:
- 26826-30-2
- Molecular formula:
- C20H42O4
- IUPAC Name:
- 2-{2-[2-(tetradecyloxy)ethoxy]ethoxy}ethanol
- Reference substance name:
- 2-[2-[2-(2-tetradecoxyethoxy)ethoxy]ethoxy]ethanol
- Cas Number:
- 39034-24-7
- Molecular formula:
- C22H46O5
- IUPAC Name:
- 2-[2-[2-(2-tetradecoxyethoxy)ethoxy]ethoxy]ethanol
- Reference substance name:
- 2-[2-[2-[2-(2-tetradecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
- Cas Number:
- 92669-01-7
- Molecular formula:
- C24H50O6
- IUPAC Name:
- 2-[2-[2-[2-(2-tetradecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
- Reference substance name:
- Hexadecan-1-ol
- EC Number:
- 253-149-0
- EC Name:
- Hexadecan-1-ol
- Cas Number:
- 36653-82-4
- Molecular formula:
- C16H34O1
- IUPAC Name:
- Hexadecan-1-ol
- Reference substance name:
- 2-(hexadecyloxy)ethanol
- EC Number:
- 218-373-5
- EC Name:
- 2-(hexadecyloxy)ethanol
- Cas Number:
- 2136-71-2
- Molecular formula:
- C18H38O2
- IUPAC Name:
- 2-(hexadecyloxy)ethanol
- Reference substance name:
- Unknown constituents
- IUPAC Name:
- Unknown constituents
- Test material form:
- liquid
- Details on test material:
- Density: ca. 0.9 mg/cm³
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Constituent 11
Constituent 12
Constituent 13
Constituent 14
Constituent 15
Constituent 16
Constituent 17
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Remarks:
- Chbb-SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. Karl Thomae GmbH, Biberach, Germany
- Weight at study initiation: 2.2 kg
- Housing: Individual housing in stainless steel cages
- Diet: K4 Alleindiät für Kaninchen, Ssniff Speziafutter GmbH, Soest, Germany, ad libitum
- Water: tap water, ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: The test item was applied to a test area of approx. 6 cm² on the dorso lateral part of the trunk, covered with a gauze patch (2.5 x 2.5 cm) and covered with a piece of polyethylene foil.
- Type of wrap if used: The patch was hold in place with an elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Remaining test substance was gently rinsed with lukewarm water.
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS: 1, 24, 48, 72 h and 6, 8, 10, 14 days
SCORING SYSTEM: Draize scoring scheme
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and #3
- Time point:
- 24/48/72 h
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- One hour after administration, 2/3 animals showed moderate to severe erythema (score 3) and 1/3 rabbits showed well-defined erythema (score 2). In addition, slight edema (2/3 rabbits) and very slight edema (1/3 rabbits) was observed. At the 24 h reading, moderate to severe erythema (score 3) was noted in 2/3 animals and severe erythema to slight eschar formation (score 4) was noted in 1/3 animals. In addition, severe edema were observed in 2/3 rabbits (score 4) and moderate edema (score 3) was noted in 1/3 rabbits. The findings became more severe in time, as all 3 rabbits showed severe erythema to slight eschar formation (score 4) and severe edema (score 4) at the 48 and 72 h reading. Erythema and edema were no longer observed in the animals on Day 6, however, scales were observed in all 3 animals, which persisted in 2/3 animals until Day 10 and in 1/3 animals until study termination on Day 14.
Any other information on results incl. tables
Table 1: Erythema findings observed during the 14 day observation period
Animal | 1 h | 24 h | 48 h | 72 h | 6 days | 8 days | 10 days | 14 days | Mean 24/48/72 h |
1 | 3 | 3 | 4 | 4 | - | - | - | - | 3.67 |
2 | 3 | 4 | 4 | 4 | - | - | - | - | 4.00 |
3 | 2 | 3 | 4 | 4 | - | - | - | - | 3.67 |
Table 2: Edema findings observed during the 14 day observation period.
Animal | 1 h | 24 h | 48 h | 72 h | 6 days | 8 days | 10 days | 14 days | Mean 24/48/72 h |
1 | 2 | 3 | 4 | 4 | - | - | - | - | 3.67 |
2 | 1 | 4 | 4 | 4 | - | - | - | - | 4.00 |
3 | 2 | 4 | 4 | 4 | - | - | - | - | 4.00 |
Table 3: Skin irritation findings
Animal | 1 h | 24 h | 48 h | 72 h | 6 days | 8 days | 10 days | 14 days |
1 | x | x | x d | x d | scp | scp det | sc det | - |
2 | - | x | x d cr | x d cr | scp cr | scp det | sc det ns | sc det |
3 | - | x | x d cr | x d cr | scp cr | scp det ns | - | - |
x: yellow stained skin in the test area; d: dry skin; cr: cracked skin; scp: scabs; sc: scales; det: detaching, ns: new skin |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
The classification of the test material is based on a very rigorous treatment of the animals with the test material. Exposure to the test material under occlusive conditions is significantly higher than under the current OECD 404 prescribed exposure under semi-occluded conditions. Higher exposures will likely result in more severe effects. Hence, the results from this study overpredict the irritation potential when assessed against new OECD 404 guidance criteria.
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