Registration Dossier
Registration Dossier
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EC number: 204-065-8 | CAS number: 115-10-6
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
DME is capable of producing sensitization of the mammalian heart to epinephrine. 5 min-NOAECdogs = 10% v/v (188426 mg/m3), 5 -min LOAECdogs = 20% v/v (188426 mg/m3).
Additional information
Epinephrine challenged dogs were evaluated in a cardiac sensitisation assay. The NOAEC was 100000 ppm (188426 mg/m3) and the LOAEC was 200000 ppm (376851 mg/m3).
The test substance did not produce adverse effects that would require classification according the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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