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Diss Factsheets
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EC number: 231-595-7 | CAS number: 7647-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: other: mitotic recombination
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified; published in 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Actual concentrations tested and number of replicates are not reported, results of positive controls are not reported, and the test was not repeated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- No guideline was stated in the report, but the study complies with the TNsG on in vitro gene mutation and is largely compliant with OECD 481
- GLP compliance:
- no
- Type of assay:
- mitotic recombination assay with Saccharomyces cerevisiae
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- Molecular formula:
- Cl H
- IUPAC Name:
- hydrogen chloride
- Details on test material:
-
Hydrochloric acid
Specification: Fisher Certified
Purity: 95% or greater
No further details specified.
Constituent 1
Method
- Target gene:
- Not applicable.
Species / strain
- Species / strain / cell type:
- other: Saccharomyces cerevisiae strain D4
- Details on mammalian cell type (if applicable):
- Nutritional deficiencies due to heteroallelism at the adenine-2 and tryptophan-5 locus.
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 derived from liver of rats previously treated with Aroclor 1254.
- Test concentrations with justification for top dose:
- 0.001-5 microlitre/plate
- Vehicle / solvent:
- no data
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Appropriate solvent (absolute ethanol) controls were used, but not reported.
- True negative controls:
- no
- Positive controls:
- yes
- Remarks:
- Appropriate positive controls were used, but not reported.
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- Way of application: The procedure followed (Brusick and Andrews, 1974) parallels the Ames/Salmonella assay with several modifications.
Method of application: in agar (plate incorporation)
Exposure Duration: 3-5 days
Incubation temperature: 30C - S9 mix, 37C + S9 mix
Number of cells evaluated: Approximately 10^7 added to plate.
Number of replicants: not specified. - Evaluation criteria:
- The result would be considered positive for induction of mitotic recombination if the test item produced a positive dose response over three concentrations with the highest increase equal to 2-3 times the solvent control value
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- Saccharomyces cerevisiae
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- with/without metabolic activation
- Cytotoxicity / choice of top concentrations:
- other: Not reported
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Actual concentrations and number of replicates tested are not reported, results of positive controls are not reported, and the test was not repeated.
- Remarks on result:
- other: other: Saccharomyces cerevisiae strain D4
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Negative results were obtained both with and without metabolic activation.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative The result would be considered positive for induction of mitotic recombination if the test item produced a positive dose response over three concentrations with the highest increase equal to 2-3 times the solvent control value
Hydrochloric acid is not mutagenic under these test conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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