Registration Dossier
Registration Dossier
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EC number: 426-110-2 | CAS number: 98377-35-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 403
- GLP compliance:
- yes
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
in der niederen Konzentrationsgruppe: (MMAD): .apprxeq. 5 µm
in der höheren Konzentrationsgruppe: (MMAD): .apprxeq. 10 µm
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU (SPF)
Administration / exposure
- Vehicle:
- other: nicht verwendet "ENGLISH" not used
- Details on inhalation exposure:
- Nur-Nase-Exposition, dynamische Expositionsbedingungen
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.04 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: .23 mg/L; Number of animals: 5; Number of deaths: 0
Male: 5.04 mg/L; Number of animals: 5; Number of deaths: 0
Female: .23 mg/L; Number of animals: 5; Number of deaths: 0
Female: 5.04 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Keine behandlungsbedingten klinischen Symptome. Reflexe am 1. Tag post expositionem unauffällig. Rektale Körpertemperaturen nicht signifikant beeinflußt. Körpergewichte und Körpergewichtszunahmen gegenüber der
- Gross pathology:
- Effects on organs:
Kein konzentrationsabhängiger Anstieg der Inzidenz von
makroskopisch-pathologischen Veränderungen bei den am Ende
der Nachbeobachtungszeit getöteten Tieren zu beobachten.
"ENGLISH"
no concentration-dependent rise of the incidence of
macroscopic-pathological changes with the animals killed
at the end of the observation-time after the experiment.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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