Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 474-260-2 | CAS number: 22841-92-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 425 (2001)
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- other: rat, Crl:CD(SD)
Administration / exposure
- Vehicle:
- other: 0,1 % Tween-80 in 0,5 % wässriger Methylcellulose.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 175 mg/kg bw
- Mortality:
- Female: 55 mg/kg bw; Number of animals: 2; Number of deaths: 0
Female: 175 mg/kg bw; Number of animals: 3; Number of deaths: 2
Female: 550 mg/kg bw; Number of animals: 1; Number of deaths: 1 - Clinical signs:
- other: Signs of toxicity related to dose levels: Ein Tier der 175 mg/kg Gruppe zeigte am Tag der Dosierung klaren oralen Ausfluss, kreisende Bewegungen und Zuckungen. Das 550 mg/kg Tier zeigte am Tag der Dosierung Koordina- tionsstörungen, dunkle Augen u
- Gross pathology:
- Effects on organs:
Es wurden keine substanzspezifischen Läsionen beobachtet.
Hautflecken wurden bei einer Ratte beobachtet. Diese waren
nicht spezifisch und nicht als Hinweis auf Toxizität am
Zielorgan zu werten.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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