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EC number: 231-793-3 | CAS number: 7733-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Assessment of the acute oral toxicity of
zinc sulphate was studied in Sprague-Dawley or Wistar rats and Swiss
mouse according to OECD guideline no 401 or 423. Soluble zinc sulphate
(monohydrate, hexahydrate and heptahydrate) has LD50 oral values ranging
from 574 to 2,949 mg/kg bw, 862 to 4,429 mg/kg bw and 920 to 4,725 mg/kg
bw, respectively for the three forms of zinc sulphate. Effects of
inhalation exposure to zinc sulphate were limited to pulmonary effects
only. Assessment of acute dermal toxicity was studied on the skin of
Wistar rats at 2000 mg/kg bw for 24 hours (OECD guideline no 402)
demonstrating zinc sulphate is not acutely toxic via the dermal route
(LD50 >2,000 mg/kg bw)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Used in EU risk assessment for zinc sulphate
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (No data about doses, controls, observation frequency, fasting period before study, age at study initiation, housing of animals)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- for more information refer to reference
- Route of administration:
- oral: gavage
- Vehicle:
- other: suspended in 0.85% saline
- Details on oral exposure:
- animals were observed for 10 days
DOSAGE PREPARATION: Solutions were administered at pH between 6.0 and 7.0. Sodium bicarbonate was used to adjust the pH when necessary.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: A preliminary screening with small groups of 3 animals was carried out The LD50 values were then calculated according to the Litchfield and Wilcoxon method. - Doses:
- 50 , 100, 500, 1000 and 3000 mg/kg
- No. of animals per sex per dose:
- 5 animals per dose
- Control animals:
- not specified
- Details on study design:
- see reference
- Statistics:
- No data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 920 mg/kg bw
- Mortality:
- no information
- Clinical signs:
- other: see reference
- Gross pathology:
- reddened stomach and intestinal mucosa
- Other findings:
- No data
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 is 920 mg/kg bw
- Executive summary:
In an acute oral study zinc sulphate (type not specified, only “Zinc sulphate, Rayon”) was suspended in 0.85% saline and administered to male Sprague Dawley rats by intubation. Dose levels were 50, 100, 500, 1000 and 3000 mg/kg (5 animals per dose). Animals were observed for ten days. Toxicity signs were reddened stomach and intestinal mucosa. The LD50value was determined as 920 mg/kg bw zinc sulphate.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 574 mg/kg bw
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Used in EU risk assessment report for zinc sulphate
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- Details on study design:
- observation period of 15 days
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: no effects
- Gross pathology:
- no effects
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 dermal is >2000 mg/kg bwZinc sulphate is not harmful or toxic via the dermal route
- Executive summary:
In this study zinc sulphate heptahydrate was administered to the skin of five Wistar rats of each sex at 2000 mg/kg bw for 24 hours. Animals were observed for 15 days. Clinical signs of toxicity consisted of erythema (grade 1 and 2, of maximum grade 4), scales and/or scabs (scale 1 and 2, of maximum scale 3) in the treated skin area between observation days 2-8.
Zinc sulphate is not harmful or toxic via the dermal route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Soluble zinc sulphate (monohydrate, hexahydrate and heptahydrate) has LD50oral values ranging from 574 to 2,949 mg/kg bw, 862 to 4,429 mg/kg bw and 920 to 4,725 mg/kg bw, respectively for the three forms of zinc sulphate. Zinc sulphate is not acutely toxic via the dermal route (LD50 >2,000 mg/kg bw). Effects of inhalation exposure to zinc sulphate were limited to pulmonary effects only.
Justification for selection of acute toxicity – oral endpoint
Lowest LD50 value.
zinc sulphate (monohydrate, hexahydrate and heptahydrate) has LD50oral values ranging from 574 to 2,949 mg/kg bw, 862 to 4,429 mg/kg bw and920 to 4,725 mg/kg bw, respectively for the three forms of zinc sulphate
Justification for classification or non-classification
Soluble zinc sulphate (monohydrate, hexahydrate and heptahydrate) has LD50oral values ranging from 574 to 2,949 mg/kg bw, 862 to 4,429 mg/kg bw and 920 to 4,725 mg/kg bw, respectively for the three forms of zinc sulphate and is classified as harmful if swallowed (Acute Tox.Cat.4: H302 ) according EC criteria. Zinc sulphate is not acutely toxic via the dermal route (LD50 >2,000 mg/kg bw). Effects of inhalation exposure to zinc sulphate were limited to pulmonary effects only.
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