Registration Dossier
Registration Dossier
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EC number: 207-838-8 | CAS number: 497-19-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 800 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Summary and discussion of acute toxicity
An acute oral toxicity study with sodium carbonate monohydrate in rats revealed an LD50 of 2,800 mg/kg bw. The acute dermal toxicity of sodium carbonate monohydrate is also low (LD50>2,000 mg/kg bw). These studies were done with sodium carbonate monohydrate but due to the relatively low water content of sodium carbonate monohydrate, the toxicity of sodium carbonate is not expected to be significantly different.
The low toxicity of sodium carbonate is confirmed by human experience. Although sodium carbonate has been used widely and for a long time, no cases of acute oral poisoning have been found in the published literature. The low oral toxicity of sodium carbonate can be explained by the neutralisation of sodium carbonate in the stomach.
Justification for classification or non-classification
Based on the available data no classification for acute toxicity is required in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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