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EC number: 215-236-1 | CAS number: 1314-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Assessment of the Toxicokinetic Behaviour
Diphosphorus pentaoxide (CAS-No. 1314-56-3)
There are no studies available in which the toxicokinetic properties of Diphosphorus pentaoxide were investigated.
Diphosphorus pentaoxide (molecular weight of 142 g/mol) is a white hygroscopic solid, which is hydrolytically unstable (formation of phosphoric acid; see chapter 4.8). The substance is an inorganic salt and therefore the log Po/wdoes not need to be derived (see chapter 4.7 partition coefficient). Due to the rapid and complete hydrolysis of Diphosphorus pentaoxide to the water soluble Phosphoric acid a general accumulation of Diphosphorus pentaoxide is unlikely to occur.
Absorption
According to EU regulation 1907/2006, AnnexVII, column 2 acute toxicity studies do not need to be conducted since the substance is corrosive.
The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system, regardless of the exposure route) will principally lead to local effects due to the strong corrosivity of the generated Phosphoric acid. Consequently, the toxicity of Phosphoric acid/Diphosphorus pentaoxide, respectively is solely based on secondary effects of corrosivity. Due to the complete hydrolysis of Diphosphorus pentaoxide the only compound which will be available systemically after exposure is Phosphate, known to be an endogenous compound and food additive without reported toxic properties.
Metabolism
Since Diphosphorus pentaoxide is corrosive, an uptake of considerable amounts of this substance is very unlikely to occur. As already discussed, the only component, which will be bioavailable after P2O5exposure is the anionic Phosphate. No further metabolism is expected to occur.
Studies on genotoxicity performed with the hydrolysis product Phosphoric acid (Ames-Test; chromosome aberration test in Chinese hamster lung cells) were negative, i.e. there is no indication of a reactivity of Diphosphorus pentaoxide or its hydrolysis product (Phosphoric acid) under the test conditions.
Excretion
The only possible metabolite/hydrolysis product Phosphate, which is the sole component to that the organism is exposed under physiological conditions after P2O5exposure, is highly water soluble and has a molecular weight lower than 500 u. Therefore, Diphosphorus pentaoxide and its metabolite/hydrolysis product Phosphate are expected to be excreted completely and predominantly via the urine.
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