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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity for rats and mice of di-2-ethylhexylphthalate with a note upon the mecanism.
Author:
Hodge HC
Year:
1943
Bibliographic source:
Proc Soc Exp Biol Med 53: 20-23

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single oral administration in rats by intraperitoneal route
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) phthalate
EC Number:
204-211-0
EC Name:
Bis(2-ethylhexyl) phthalate
Cas Number:
117-81-7
Molecular formula:
C24H38O4
IUPAC Name:
1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate

Test animals

Species:
rat
Strain:
other: albino
Sex:
not specified
Details on test animals or test system and environmental conditions:
- Weight at study initiation: 149-198g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
3100, 5700, 12700, 18100, 19200, 23800 mg/kg
No. of animals per sex per dose:
5, 5, 5, 5, 15 and 15 rats in groups treated at 3100, 5700, 12700, 18100, 19200 and 2380 mg/kg respectively.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 5, 7 and 10 days
- Organ were weighted

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 23 800 mg/kg bw
Remarks on result:
other: intraperitoneal
Mortality:
No mortality was observed.
Other findings:
the average liver weights were 8.8, 7.8 and 7.3 g in animals killed 5 days, 7 days and 10 days after the injection, respectively.

Any other information on results incl. tables

Nb of rats Average body weight (g) Dose (mg/kg) Effects
15 198 23800 Diarrhea
15 196 19200 Some diarrhea
5 155 18100  -
5 149 12700 None
5 159 5700 None
5 159 3100 None

Applicant's summary and conclusion

Conclusions:
Under these experimental conditions, the LD50 was estimated to be higher than 23800 mg/kg in rats by the intraperitoneal route.