Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-893-7 | CAS number: 111-66-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable not assignable because this study only examined one dose level, and systemic toxicity was not evaluated.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable not assignable because this study only examined one dose level, and systemic toxicity was not evaluated.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- Deviations:
- yes
- GLP compliance:
- no
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data reported with regard to test animals or environmental conditions.
IN-LIFE DATES: From: not reported To: 28 days later - Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- No data was reported with regard to area of exposure, percentage of coverage, type of wrap (if used), or time intervals for shavings/clippings.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 millilitres
- Constant volume or concentration used: Yes - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- No data reported.
- Frequency of treatment:
- 5 days a week for 4 weeks for a total of 20 applications
- Remarks:
- Doses / Concentrations:
0.2 millilitres
Basis:
no data - No. of animals per sex per dose:
- Six animals per dose (3 intact and 3 abraded)
- Control animals:
- no
- Details on study design:
- No data reported.
- Positive control:
- None
- Observations and examinations performed and frequency:
- There were no data reported regarding whether cageside observations or detailed clinical observations were performed. Additionally, there were no data reported with regard to the methods used (if any) for following examinations: body weight, food consumption, food efficiency, water consumption, ophthalmoscopic, haematology, clinical chemistry, urinalysis, and neurobehavioural.
DERMAL IRRITATION (if dermal study): Yes
- Time schedule for examinations: 24 hours after each application
- Sacrifice and pathology:
- Methods for gross pathology or histopathology examinations were not reported.
- Statistics:
- No data reported.
- Clinical signs:
- not specified
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- OTHER FINDINGS: The study authors reported that animals exposed to 1-octene exhibited questionable hyperaemia, exfoliation, and scab formation.
- Dose descriptor:
- NOAEL
- Sex:
- not specified
- Basis for effect level:
- other: Report only specified dermal irritation and results indicated questionable irritation.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
- Critical effects observed:
- not specified
- Conclusions:
- Using a graded scale of 1 to 6 (none to severe), treatment with 1-octene for 28 days (20 treatments) caused an average score of approximately 2 (considered questionable) for hyperaemia, exfoliation, and scab formation.
- Executive summary:
In a 28-day dermal toxicity study, alpha olefin 8 was applied to the shaved skin of six New Zealand white rabbits (3 intact and 3 abraded) at a dose level of 0.2 millilitres for 5 days/week during a 28-day period.
The skin was ranked using a graded system by the study authors ranging from 1 (none) to 6 (severe). The average score for hyperaemia, exfoliation, and scab formation was approximately 2 (considered questionable). There were no other toxicity results reported. Therefore, no LOAEL or NOAEL were identified.
This study received a Klimisch score of 4 and is classified as not assignable because this study only examined one dose level, and systemic toxicity was not evaluted.
This study was selected as a supporting study because there was only was dose level examined and systemic toxicity was not evaluated; however, the study contains relevant and useful information, allowing this study to qualify as a supporting study.
The average results for the hyperaemia, exfoliation and scab formation were approximately 2, which fell into the study authors questionable grade. There was no difference in reaction between the abraded and intact animals.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study)
- Deviations:
- yes
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 111-66-0
- Molecular formula:
- C8H16
- Details on test material:
- - Name of test material (as cited in study report): Alpha olefin C8
- Substance type: C8 alpha olefin
- Physical state: Liquid
- Other: Density was 0.716 g/mL
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data reported with regard to test animals or environmental conditions.
IN-LIFE DATES: From: not reported To: 28 days later
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- No data was reported with regard to area of exposure, percentage of coverage, type of wrap (if used), or time intervals for shavings/clippings.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 millilitres
- Constant volume or concentration used: Yes - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- No data reported.
- Frequency of treatment:
- 5 days a week for 4 weeks for a total of 20 applications
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2 millilitres
Basis:
no data
- No. of animals per sex per dose:
- Six animals per dose (3 intact and 3 abraded)
- Control animals:
- no
- Details on study design:
- No data reported.
- Positive control:
- None
Examinations
- Observations and examinations performed and frequency:
- There were no data reported regarding whether cageside observations or detailed clinical observations were performed. Additionally, there were no data reported with regard to the methods used (if any) for following examinations: body weight, food consumption, food efficiency, water consumption, ophthalmoscopic, haematology, clinical chemistry, urinalysis, and neurobehavioural.
DERMAL IRRITATION (if dermal study): Yes
- Time schedule for examinations: 24 hours after each application
- Sacrifice and pathology:
- Methods for gross pathology or histopathology examinations were not reported.
- Statistics:
- No data reported.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- OTHER FINDINGS: The study authors reported that animals exposed to 1-octene exhibited questionable hyperaemia, exfoliation, and scab formation.
Effect levels
- Dose descriptor:
- NOAEL
- Sex:
- not specified
- Basis for effect level:
- other: Report only specified dermal irritation and results indicated questionable irritation.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The average results for the hyperaemia, exfoliation and scab formation were approximately 2, which fell into the study authors questionable grade. There was no difference in reaction between the abraded and intact animals.
Applicant's summary and conclusion
- Conclusions:
- Using a graded scale of 1 to 6 (none to severe), treatment with 1-octene for 28 days (20 treatments) caused an average score of approximately 2 (considered questionable) for hyperaemia, exfoliation, and scab formation.
- Executive summary:
In a 28-day dermal toxicity study, alpha olefin 8 was applied to the shaved skin of six New Zealand white rabbits (3 intact and 3 abraded) at a dose level of 0.2 millilitres for 5 days/week during a 28-day period.
The skin was ranked using a graded system by the study authors ranging from 1 (none) to 6 (severe). The average score for hyperaemia, exfoliation, and scab formation was approximately 2 (considered questionable). There were no other toxicity results reported. Therefore, no LOAEL or NOAEL were identified.
This study received a Klimisch score of 4 and is classified as not assignable because this study only examined one dose level, and systemic toxicity was not evaluted.
This study was selected as a supporting study because there was only was dose level examined and systemic toxicity was not evaluated; however, the study contains relevant and useful information, allowing this study to qualify as a supporting study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)