Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-933-1 | CAS number: 12042-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 13/02/1996 - 08/03/1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Test was not performed according to GLP. Actual test concentrations of the test substance were not measured. Strain and origin of test species are not reported. A polymer is reported to have been added to the test medium, but its purpose is not clear. The study was performed on Ceriodaphnia and not on Daphnia magna nevertheless a nOEC and LOEC was obtained and the study is considered acceptable for risk assessment purposes.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: USEPA (EPA 600/4-89/001)
- Deviations:
- yes
- Remarks:
- One organism in replicate 3 of the 1.9 mg/l treatment died due to a labaratory induced mortality. This organism was excluded from data analysis.
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not relevant - Analytical monitoring:
- no
- Details on sampling:
- Daily samples were taken to monitor physical/chemical conditions. Samples were cold-stored between renewals.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Batches of 300 ml were prepared daily from a 1000 ppm stock solution using a pre-determined dilution plan.
- Controls: Yes
- Evidence of undissolved material (e.g. precipitate, surface film, etc): No, test substance concentration was below maximum solubility - Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Common name: Ceriodaphnia dubia
- Age of parental stock (mean and range, SD): Less than 24 hours, all released within 8 hour period of aech other
- Feeding during test
- Food type: YTC and algal suspension
- Amount: 0.1 ml / test chamber
- Frequency: daily - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 8 d
- Remarks on exposure duration:
- Test lasts until 60% of the control females have produced three broods
- Post exposure observation period:
- Not relevant
- Hardness:
- 80 - 92 mg/l (not specified)
- Test temperature:
- 24.5 - 25.5 degrees Celsius
- pH:
- 7.8 - 8.2
- Dissolved oxygen:
- 7.5 - 8.4 mg/l
- Salinity:
- Not relevant
- Nominal and measured concentrations:
- Nominal: 1.9, 3.8, 7.5, 15 and 31 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: size: 30ml; filled with 15-20 ml medium
- Aeration: none
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- No. of vessels per vehicle control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Moderately hard synthetic water (prepared using deionized water and reagent grade chemicals) or suitable natural water.
- Intervals of water quality measurement: daily
OTHER PARAMETERS
- Photoperiod: 16/8 hours light/dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : survival and reproduction were observed daily - Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride
- Duration:
- 8 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 8 d
- Dose descriptor:
- other: MATC
- Effect conc.:
- 5.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 8 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 7.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 8 d
- Dose descriptor:
- other: IC25
- Effect conc.:
- 5.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - Survival of parent animals: 80%, 89%, 100%, 90%, 80% and 100% at 0, 1.9, 3.8, 7.5, 15 and 31 mg/l respectively.
- No. of offspring produced per day per female: 15.1, 17.9, 17.2, 4.8, 3.3 and 1.2 at 0, 1.9, 3.8, 7.5, 15 and 31 mg/l respectively.
- Other biological observations: adults and neonates appeared to be healthy during the test - Results with reference substance (positive control):
- - Results with reference substance valid?: yes, 48h-LC50 of 1.9 g/l is within range of 1.3 to 2.5 mg/l.
- Reported statistics and error estimates:
- Statistical analysis was done using Fisher exact tests and bootstrapping methods.
- Validity criteria fulfilled:
- yes
- Remarks:
- minimum acceptable survival and reproduction criteria were met or exceeded in the control
- Conclusions:
- The chronic NOEC, MATC, LOEC and IC25 values of Sumalchlor towards Ceriodaphnia dubia are 3.8, 5.3, 7.5 and 5.1 mg/l respectively.
- Executive summary:
The chronic toxicity of Sumalchlor towards Ceriodaphnia dubia was investigated according to USEPA guideline EPA 600/4 -89/001. Validity criteria for the test were met. The test was performed by Inchcape Testing Servives as ordered by Summit Research Labs. Sumalchlor was tested at concentrations of 1.9, 3.8, 7.5, 15 and 31 mg/l in moderately hard water. No relationship between test substance concentration and survival was observed. Actual concentrations of the test substance were not measured. The chronic NOEC, MATC, LOEC and IC25 were found to be 3.8, 5.3, 7.5 and 5.1 mg/l respectively.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 30/01/1996 - 08/03/1996
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Test was not performed according to GLP. Actual test concentrations of the test substance were not measured. Strain and origin of test species are not reported. A polymer is reported to have been added to the test medium, but its purpose is not clear. As no NOECD was obtained the data cannot be used for risk assessment purposes directly
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: USEPA (EPA 600/4-89/001)
- Deviations:
- yes
- Remarks:
- One organism in replicate 3 of the 1.9 mg/l treatment died due to a labaratory induced mortality. This organism was excluded from data analysis.
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not relevant - Analytical monitoring:
- no
- Details on sampling:
- Daily samples were taken to monitor physical/chemical conditions. Samples were cold-stored between renewals.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Batches of 300 ml were prepared daily from a 1000 ppm stock solution using a pre-determined dilution plan.
- Controls: Yes
- Evidence of undissolved material (e.g. precipitate, surface film, etc): No, test substance concentration was below maximum solubility - Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Common name: Ceriodaphnia dubia
- Age of parental stock (mean and range, SD): Less than 24 hours, all released within 8 hour period of aech other
- Feeding during test
- Food type: YTC and algal suspension
- Amount: 0.1 ml / test chamber
- Frequency: daily - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Remarks on exposure duration:
- Test lasts until 60% of the control females have produced three broods
- Post exposure observation period:
- Not relevant
- Hardness:
- 80 - 88 mg/l (not specified)
- Test temperature:
- 24.6 - 25.7 degrees Celsius
- pH:
- 7.2 - 8.2
- Dissolved oxygen:
- 8.0 - 8.3 mg/l
- Salinity:
- Not relevant
- Nominal and measured concentrations:
- Nominal: 15, 31, 62, 125 and 250 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: size: 30ml; filled with 15-20 ml medium
- Aeration: none
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- No. of vessels per vehicle control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Moderately hard synthetic water (prepared using deionized water and reagent grade chemicals) or suitable natural water.
- Intervals of water quality measurement: daily
OTHER PARAMETERS
- Photoperiod: 16/8 hours light/dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : survival and reproduction were observed daily - Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 7 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 7 d
- Dose descriptor:
- other: IC25
- Effect conc.:
- 3.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - Survival of parent animals: 100%, 70%, 100%, 60%, 90% and 40% at 0, 15, 31, 62, 125 and 250 mg/l respectively.
- No. of offspring produced per day per female: 19.2, 0.0, 0.9, 0.3, 0.1 and 0.0 at 0, 15, 31, 62, 125 and 250 mg/l respectively.
- Other biological observations: adults and neonates appeared to be healthy during the test - Results with reference substance (positive control):
- - Results with reference substance valid?: yes, 48h-LC50 of 1.9 g/l is within range of 1.3 to 2.5 mg/l.
- Reported statistics and error estimates:
- Statistical analysis was done using Fisher exact tests and bootstrapping methods.
- Validity criteria fulfilled:
- yes
- Remarks:
- minimum acceptable survival and reproduction criteria were met or exceeded in the control
- Conclusions:
- The chronic NOEC, LOEC and IC25 values of Sumalchlor towards Ceriodaphnia dubia are <15, 15, and 3.8 mg/l respectively.
- Executive summary:
The chronic toxicity of Sumalchlor towards Ceriodaphnia dubia was investigated according to USEPA guideline EPA 600/4 -89/001. Validity criteria for the test were met. The test was performed by Inchcape Testing Servives as ordered by Summit Research Labs. Sumalchlor was tested at concentrations of 15, 31, 62, 125 and 250 mg/l in moderately hard water. No relationship between test substance concentration and survival was observed. Actual concentrations of the test substance were not measured. The chronic NOEC, LOEC and IC25 were found to be <15, 15 and 3.8 mg/l respectively.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 13/02/1996 - 08/03/1996
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Test was not performed according to GLP. Actual test concentrations of the test substance were not measured. Strain and origin of test species are not reported. A polymer is reported to have been added to the test medium, but its purpose is not clear. Furthermore as no NOEC was obtained the study cannot be used for risk assessment purposes
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: USEPA (EPA 600/4-89/001)
- Deviations:
- yes
- Remarks:
- One organism in replicate 3 of the 1.9 mg/l treatment died due to a labaratory induced mortality. This organism was excluded from data analysis.
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not relevant - Analytical monitoring:
- no
- Details on sampling:
- Daily samples were taken to monitor physical/chemical conditions. Samples were cold-stored between renewals.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Batches of 300 ml were prepared daily from a 1000 ppm stock solution using a pre-determined dilution plan.
- Controls: Yes
- Evidence of undissolved material (e.g. precipitate, surface film, etc): No, test substance concentration was below maximum solubility - Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Common name: Ceriodaphnia dubia
- Age of parental stock (mean and range, SD): Less than 24 hours, all released within 8 hour period of aech other
- Feeding during test
- Food type: YTC and algal suspension
- Amount: 0.1 ml / test chamber
- Frequency: daily - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 8 d
- Remarks on exposure duration:
- Test lasts until 60% of the control females have produced three broods
- Post exposure observation period:
- Not relevant
- Hardness:
- 80 - 92 mg/l (not specified)
- Test temperature:
- 24.5 - 25.6 degrees Celsius
- pH:
- 7.2 - 8.2
- Dissolved oxygen:
- 7.6 - 8.3 mg/l
- Salinity:
- Not relevant
- Nominal and measured concentrations:
- Nominal: 15, 31, 62, 125 and 250 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: size: 30ml; filled with 15-20 ml medium
- Aeration: none
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
- No. of vessels per vehicle control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Moderately hard synthetic water (prepared using deionized water and reagent grade chemicals) or suitable natural water.
- Intervals of water quality measurement: daily
OTHER PARAMETERS
- Photoperiod: 16/8 hours light/dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : survival and reproduction were observed daily - Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride
- Duration:
- 8 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 8 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 8 d
- Dose descriptor:
- other: IC25
- Effect conc.:
- 4.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - Survival of parent animals: 80%, 100%, 90%, 100%, 70% and 80% at 0, 15, 31, 62, 125 and 250 mg/l respectively.
- No. of offspring produced per day per female: 17.1, 3.7, 2.5, 2.0, 1.0 and 1.0 at 0, 15, 31, 62, 125 and 250 mg/l respectively.
- Other biological observations: adults and neonates appeared to be healthy during the test - Results with reference substance (positive control):
- - Results with reference substance valid?: yes, 48h-LC50 of 1.9 g/l is within range of 1.3 to 2.5 mg/l.
- Reported statistics and error estimates:
- Statistical analysis was done using Fisher exact tests and bootstrapping methods.
- Validity criteria fulfilled:
- yes
- Remarks:
- minimum acceptable survival and reproduction criteria were met or exceeded in the control
- Conclusions:
- The chronic NOEC, LOEC and IC25 values of Sumalchlor towards Ceriodaphnia dubia are <15, 15, and 4.8 mg/l respectively.
- Executive summary:
The chronic toxicity of Sumalchlor towards Ceriodaphnia dubia was investigated according to USEPA guideline EPA 600/4 -89/001. Validity criteria for the test were met. The test was performed by Inchcape Testing Servives as ordered by Summit Research Labs. Sumalchlor was tested at concentrations of 15, 31, 62, 125 and 250 mg/l in moderately hard water. No relationship between test substance concentration and survival was observed. Actual concentrations of the test substance were not measured. The chronic NOEC, LOEC and IC25 were found to be <15, 15 and 4.8 mg/l respectively.
Referenceopen allclose all
Conc substance (in mg/L) |
% survival |
Reproduction (average no. of neonates/female |
Control |
80 |
15.1 |
1.9 |
89 |
17.9 |
3.8 |
100 |
17.2 |
7.5 |
90 |
4.8* |
15 |
80 |
3.3* |
31 |
100 |
1.2* |
Values marked with "*" are significantly different from control values (P<0.05)
Conc substance (in mg/L) |
% survival |
Reproduction (average no. of neonates/female |
Control |
100 |
19.2 |
15 |
70 |
0.0* |
31 |
100 |
0.9* |
62 |
60 |
0.3* |
125 |
90 |
0.1* |
250 |
40 |
0.0* |
Values marked with "*" are significantly different from control values (P<0.05)
Conc substance (in mg/L) |
% survival |
Reproduction (average no. of neonates/female |
Control |
80 |
17.1 |
15 |
100 |
3.7* |
31 |
90 |
2.5* |
62 |
100 |
2.0* |
125 |
70 |
1.0* |
250 |
80 |
1.0* |
Values marked with "*" are significantly different from control values (P<0.05)
Description of key information
USEPA 600/4 -89/001, key study, validity 2 (Williams, 1996):
NOEC < 15 mg/L, LOEC = 15 mg/L, IC25 = 3.8 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 15 mg/L
Additional information
Three read-across studies performed on Aluminium chloride hydroxide are available. The first referenced study is a key study while the two others are supporting studies.
1) The chronic toxicity of Sumalchlor towards Ceriodaphnia dubia was investigated according to USEPA guideline EPA 600/4 -89/001. Validity criteria for the test were met. The test was performed by Inchcape Testing Servives as ordered by Summit Research Labs. Sumalchlor was tested at concentrations of 15, 31, 62, 125 and 250 mg/L in moderately hard water. No relationship between test substance concentration and survival was observed. Actual concentrations of the test substance were not measured. The chronic NOEC, LOEC and IC25 were found to be <15, 15 and 3.8 mg/L respectively.
2) The chronic toxicity of Sumalchlor towards Ceriodaphnia dubia was investigated according to USEPA guideline EPA 600/4 -89/001. Validity criteria for the test were met. The test was performed by Inchcape Testing Servives as ordered by Summit Research Labs. Sumalchlor was tested at concentrations of 15, 31, 62, 125 and 250 mg/L in moderately hard water. No relationship between test substance concentration and survival was observed. Actual concentrations of the test substance were not measured. The chronic NOEC, LOEC and IC25 were found to be <15, 15 and 4.8 mg/L respectively.
3) The chronic toxicity of Sumalchlor towards Ceriodaphnia dubia was investigated according to USEPA guideline EPA 600/4 -89/001. Validity criteria for the test were met. The test was performed by Inchcape Testing Servives as ordered by Summit Research Labs. Sumalchlor was tested at in moderately hard water. No relationship between test substance concentration and survival was observed. Actual concentrations of the test substance were not measured. The chronic NOEC, MATC, LOEC and IC25 were found to be 3.8, 5.3, 7.5 and 5.1 mg/L respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.