Registration Dossier
Registration Dossier
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EC number: 208-915-9 | CAS number: 546-93-0
Carcinogenicity
Administrative data
Description of key information
Magnesium carbonate is not expected to pose a risk of carcinogenicity.
Key value for chemical safety assessment
Justification for classification or non-classification
No carcinogenicity classification is warranted for magnesium carbonate according to either the DSD or CLP based on evidence from genotoxicity, repeat dose studies and long term human studies.
Additional information
There are no lifetime animal studies available on magnesium carbonate in order to directly investigate its possible carcinogenic activity. Genotoxicity and repeat-dose toxicity studies on magnesium chloride are available and have been read across to magnesium carbonate. No evidence of mutagenic potential was seen in the genotoxicity studies with magnesium chloride and repeat dose studies showed no evidence of hyperplasia or pre-neoplastic lesions. Furthermore, the long term human data do not provide any indications of carcinogenicity.
Moreover, magnesium is essential for life and is ubiquitous in the natural environment. Humans are widely exposed to naturally occurring magnesium carbonate and chloride, e.g. via drinking water and food on a day to day basis. Ingested magnesium, carbonate and chloride ions are actively regulated by the body and are therefore not considered to be systemically toxic in standard test systems.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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