Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-08-08 to 1991-08-22
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Reason for RL- rating: according to Guidance on information requirements and chemical safety assessment Chapter R. 7a: Endpoint specific guidance, inhaled particles should have a MMAD between 1 and 4 microns. The MMAD in this study was slightly above the recommened value.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
1981-05-12
Deviations:
yes
Remarks:
no vehicle control group was used; no acclimatisation period was stated; it was not stated if a dynamic air flow of 12 to 15 air changes per hour was used; no equilibrium period was stated; clinical observations only at least once on workday
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1