Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-08-08 to 1991-08-22
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Reason for RL- rating: according to Guidance on information requirements and chemical safety assessment Chapter R. 7a: Endpoint specific guidance, inhaled particles should have a MMAD between 1 and 4 microns. The MMAD in this study was slightly above the recommened value.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
1981-05-12
Deviations:
yes
Remarks:
no vehicle control group was used; no acclimatisation period was stated; it was not stated if a dynamic air flow of 12 to 15 air changes per hour was used; no equilibrium period was stated; clinical observations only at least once on workday
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material