Registration Dossier
Registration Dossier
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EC number: 201-185-2 | CAS number: 79-20-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study
Data source
Reference
- Reference Type:
- publication
- Title:
- Physical-Chemical-Activity Relationship of Organic Solvents: Effects on Na+-K+-ATPase Activity and Membrane Fluidity in Mouse Synaptosomes.
- Author:
- Tanii H, Huang J, Ohyashiki T, Hashimoto K
- Year:
- 1 994
- Bibliographic source:
- Neurotoxicology and Teratology 16(6): 575-582
Materials and methods
- Type of study / information:
- Physical-chemical-activity relationship of methyl acetate (and other solvents): Effects on Na+-K+-ATPase activity and membrane fluidity in mouse synaptosomes.
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Type: other
Method: other - GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- methyl acetate
- Details on test material:
- analytical purity
Constituent 1
Results and discussion
Any other information on results incl. tables
The IC50 (mM) (Na+-K+ ATPase Activity) for methyl acetate: 682
The IC12.5 (mM) (Membrane-DPH Anisotropy) for methyl acetate: 350
Log P (P=n-octanol/water partition coefficient) for methyl acetate: 0.05 (values in literature 0.18 and 0.17).
Methyl acetate had the highest IC50 (Na+-K+ ATPase Activity) and IC12.5 (Membrane-DPH Anisotropy). Therefore the toxic ability to affect membrane environment was the least among all substances tested.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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