Registration Dossier
Registration Dossier
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EC number: 208-863-7 | CAS number: 544-17-2
Carcinogenicity
Administrative data
Description of key information
Potassium diformate lacked potential for carcinogenicity in rodents (rats and mice). This can be extrapolated to formic acid and other formate salts including calcium diformate and supports the finding that calcium diformate is not genotoxic.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 2 000 mg/kg bw/day
Justification for classification or non-classification
No classification. Criteria of regulations 67/548/EC and 1272/2008/EC not met.
Additional information
Potassium diformate (up to 2000 mg/kg bw/day) did not show potential for carcinogenicity in two valid long-term rodent feed studies using rats and mice, respectively. This can be extrapolated to formic acid and other formate salts.
The tested formate dose compares to 2000 mg calcium diformate/kg bw/day.
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