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EC number: 218-216-0 | CAS number: 2082-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Not readily biodegradable (according to OECD criteria); inherently biodegradable
Key value for chemical safety assessment
Additional information
Based on the studies as presented in this chapter, octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate seems to be hydrolysed in a biotic process to benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy- (“Metilox acid” CAS: 20170-32-5) and 1-octadecanol (CAS: 112-92-5).
3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate reached a mineralisation of 32 % in 29 days in an OECD 301B–test (CO2-evolution, CIBA 1984). Another test, reports, that up to 47 % of the substance was degraded in 35 days in an OECD 302B –test (RL3, CIBA 1991).
CERI (1996) has also reported on a ready biodegradability test (OECD 301C). With 100 mg/l test concentration, 21-39 % mineralization was observed after 28 days (measured as BOD) and metilox acid was observed to be formed. Primary degradation was based on metilox acid formation 62-93 % of the parent substance concentration. 1-Octadecanol was not detected suggesting that it was further degraded.
A ready biodegradation test according to OECD 301A (DOC Die away) has been conducted by RCC Ltd. (2006). A test concentration of 0.1 mg/l and predominantly domestic sludge (final conc. 30 mg/l SS) were used and degradation was measured by means of monitoring the concentration of the parent compound and the anticipated degradation product metilox acid with LC-MS (LOQ = 0.003 mg/l for the parent compound, LOQ = 0.001 mg/ for metilox acid). Only the inoculum and procedure controls were followed by means of DOC. Acetone was used as solvent. Removal of the parent compound was 85 % in 10 days. Primary degradation was observed as Metilox acid was detected in the same samples analysed for the parent compound, and the concentrations increased from 0.005 mg/l on day 1 to mean concentrations between 0.024 mg/l and 0.037 mg/l on days 2 to 10. In the abiotic control, the concentration of the test item decreased by 47 % over the incubation period of 10 days. However, no quantifiable concentrations of metilox acid were found. Loss of the parent compound could therefore probably be attributed to sorption to the glass walls.
Fischer et al. (1999) investigated the degradation of 14C-octadecyl 3-(3,5-di-tert-butyl-4 -hydroxyphenyl)propionate (50 μg/L) after incubation for five days at 25°C with constant stirring by activated sludge. The overall mass balance was low at 76.9% based on the initial amount of 14C added. Ca. 0.1% of the applied radioactivity was recovered as CO2, 69.8% as extractable products and 7.0% as non-extractable products. The extractable products were found to contain around 10.5% of 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid methyl ester, 7.7% unchanged octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and 53.6% unknown products.
In conclusion, 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is not readily biodegradable. However, significant biodegradation was observed under ready biodegradability conditions. Therefore the substance can be considered as inherently biodegradable.
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