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EC number: 215-684-8 | CAS number: 1344-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation
The two studies in skin irritation with the test substance Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) showed no evidence of erythema or edema.
The studies in the structurally related read-across substances showed only mild responses not meeting GHS criteria for classification.
Eye Irritation
There is only one reliable study in one nanoform of Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) which produced only slight and short-term irritation, not meeting GHS criteria for classification. A second study in the same form of substance, that did not show ocular irritation, cannot be used for classification, because contradictory to the current guideline the eyes were rinsed. Another study in two other forms of Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) also cannot be used for classification, since there are no individual animal scores provided in its report. But it produced in any case only mild and reversible effects. Yet another study in another form of Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) is also unassessable for classification due to ambiguous results making impossible a stand-alone prediction according to OECD 491.
An in-vitro study in the structurally related read-across substance Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS) measured a relative tissue viability of 88.7%, thereby not meeting GHS criteria for classification.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Fed. Hazardous Substances Act, Section 101.11
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Zeolex 7
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: abraded and intact (shaved)
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- Scoring after 24 and 72 h after test initiation
- Number of animals:
- 6
- Details on study design:
- The procedure described in Section 101.11 of the Federal Hazardous Substances Act was followed. Irritation to the skin was measured by the patch test technique using the albino rabbit. Six healthy New Zealand rabbits were used to determine the irritation potential of each test material. Each animal received two applications of the assigned test material; one application to an intact and one application to an abraded skin area clipped free of hair. Surgical gauze (1 inch x 1 inch) secured in place by adhesive tape was used to cover the treated sites. Each animal received 0.5 grams of test material at each test site.
The entire trunk of each animal was then wrapped in plastic to prevent loss of the sample. Contact of the test material with the skin was maintained for 24 hours, after which the plastic and gauze were removed and the treated areas gently cleansed. The treated areas were scored according to the Federal Hazardous Substances Act, 24 and 72 hours after initiation of the test. - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 / 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #1 - #6
- Time point:
- 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #1 - #6
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 - #6
- Time point:
- 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 - #6
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No evidence of erythema or edema was observed following topical application of the test material to any of the rabbits.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No evidence of erythema or edema was observed following topical application of the test material to any of the rabbits.
- Executive summary:
The skin irritation potential of the Sodium silicoaluminate Zeolex 7 was investigated in six rabbits according to the Federal Hazardous Substances Act. No evidence of erythema or edema was observed within 72 hours.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Fed. Hazardous Substances Act, Section 101.11
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Zeolex 23A
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: abraded and intact (shaved)
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- Scoring after 24 and 72 h after test initiation
- Number of animals:
- 6
- Details on study design:
- The procedure described in Section 101.11 of the Federal Hazardous Substances Act was followed. Irritation to the skin was measured by the patch test technique using the albino rabbit. Six healthy New Zealand rabbits were used to determine the irritation potential of each test material. Each animal received two applications of the assigned test material; one application to an intact and one application to an abraded skin area clipped free of hair. Surgical gauze (1 inch x 1 inch) secured in place by adhesive tape was used to cover the treated sites. Each animal received 0.5 grams of test material at each test site.
The entire trunk of each animal was then wrapped in plastic to prevent loss of the sample. Contact of the test material with the skin was maintained for 24 hours, after which the plastic and gauze were removed and the treated areas gently cleansed. The treated areas were scored according to the Federal Hazardous Substances Act, 24 and 72 hours after initiation of the test. - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 / 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #1 - #6
- Time point:
- 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #1 - #6
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 - #6
- Time point:
- 72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 - #6
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No evidence of erythema or edema was observed following topical application of the test material to any of the rabbits.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No evidence of erythema or edema was observed following topical application of the test material to any of the rabbits.
- Executive summary:
The skin irritation potential of the Sodium silicoaluminate Zeolex 23A was investigated in six rabbits according to the Federal Hazardous Substances Act. No evidence of erythema or edema was observed within 72 hours.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sep. 6-18, 2019, experimental phase: Sep. 9-12, 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- 2019
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Name: Silicic acid, magnesium aluminium sodium salt
Batch no.: 1901274010
Appearance: white fluffy powder
Composition: Sodium; Magnesium; Aluminium; Silica
Purity: >95%
Homogeneity: homogeneous - Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Duration of treatment / exposure:
- 6 h
- Duration of post- treatment incubation (in vitro):
- 18 h
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- - Negative Control: Sterile demineralised water, prepared by LAUS GmbH using an ion exchanger and membrane filtration through sterile filters, batch no.: T20190717.
- Positive Control: Methyl acetate (C3H6O2, CAS No. 79-20-9), procured from MatTek, batch no.: 021319ISC.
- Test System: Commercially available EpiOcular(TM) kit.
The EpiOcular tissue consists of normal, human-derived keratinocytes which have been cultured to form a stratified squamous epithelium similar to that found in the human cornea. It consists of highly organized basal cells. These cells are not transformed or transfected with genes to induce an extended life span. The EpiOcular tissues are cultured in specially prepared cell culture inserts with a porous membrane through which nutrients can pass to the cells. The tissue surface is 0.6 cm².
- MTT solution: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (=MTT), which can be reduced to a blue formazan, prepared by LAUS GmbH.
A MTT stock solution of 5 mg/mL in DPBS buffer was prepared and stored in aliquots of 2 mL at – 20 ± 5 °C. 2 mL of the stock solution were thawed and diluted with 8 mL of assay medium (resulting in 1 mg/mL). This MTT-solution with the concentration of 1 mg/mL was used in the test. - Irritation parameter:
- in vitro irritation score
- Run / experiment:
- relative tissue viability
- Value:
- ca. 86.3 - ca. 91
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the test, Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS) is considered non-eye irritant in the EpiOcular(TM) Eye Irritation Test.
- Executive summary:
The test item Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS) was applied to a three-dimensional human cornea tissue model in duplicate for an exposure time of 6 hours.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Fed. Hazardous Substance Act Section 191.12 (1973)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Zeolex 23A
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- once, unrinsed
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- A single application of the test sample (100 mg of a solid) full strength was made into the conjunctival sac of the right eye of six rabbits. The eyelids were held closed for one second. The left eye served as the control.
The eyes were examined and the grade of ocular reaction recorded at 24, 48 and 72 hours following application. Reading of reactions was facilitated by the use of a hand-held ophthalmoscope. After the recording of observations, the eyes were stained with sodium fluorescein and examined with an ultra-violet lamp to detect possible corneal damage.
The reactions were based on the " Illustrated Guide for Grading Eye Irritation by Hazardous Sabstances", Federal Hazardous Substances Act Regulations. - Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- iris score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Only on day 1, effect scores of 1 for conjunctivae and chemosis were observed in many animals, and in one animal score 2 for conjunctivae. Cornea and iris remained unaffected. No irritating effects were seen anymore after 48 h or later.
- Interpretation of results:
- not irritating
- Conclusions:
- Based on the results of this study, Zeolex 23A would not be considered an ocular irritant.
- Executive summary:
Zeolex 23 A was tested according to the regulations of the Federal Hazardous Substances Act without rinsing. According to this and also modern GHS it would not be considered an ocular irritant.
Referenceopen allclose all
Measured Values
As blank, the optical density of isopropanol was measured in eight wells of the 96-well-plate. The measured values and their mean are given in the following table:
Table 9.1-a : Absorbance Values Blank Isopropanol (OD at 570 nm)
Replicate 1 2 3 4 5 6 7 8 Mean
Absorbance 0.032 0.033 0.033 0.034 0.034 0.034 0.033 0.035 0.034
The absorbance values of negative control, test item and positive control are given in the following table:
Table 9.1-b: Absorbance Values Negative Control, Positive Control and Test Item (OD at 570 nm)
Designation Measurement Negative Control Positive Control Silicic acid, magnesium aluminium sodium salt
Tissue 1 1 1.878 0.791 1.671
2 1.889 0.772 1.658
Tissue 2 1 1.771 0.866 1.586
2 1.761 0.859 1.574
From the measured absorbances, the mean of each tissue was calculated, subtracting the mean absorbance of isopropanol as given in table 9.1-a (= corrected values).
Table 9.1-c: Mean Absorbance Negative Control, Positive Control and Test Item
Designation Negative Control Positive Control Silicic acid, magnesium aluminium sodium salt
Mean – blank (Tissue 1) 1.850 0.748 1.631
Mean – blank (Tissue 2) 1.732 0.829 1.546
Comparison of Tissue Viability
For the test item and the positive control, the following percentage values of tissue viability were calculated in comparison to the negative control:
Table 9.2-a: % Viability Positive Control and Test Item
Designation Positive Control Silicic acid, magnesium aluminium sodium salt
% Viability (Tissue 1) 41.7% 91.0%
% Viability (Tissue 2) 46.3% 86.3%
% Viability Mean 44.0% 88.7%
Eye hazard potential was assessed using the criteria given in the following table:
Table 9.3-a: Assessment of Eye Hazard Potential
% Viability Assessment UN GHS classification
> 60 % Non eye irritant No Category
≤ 60 % At least eye irritant No prediction can be made (category 1 or 2)
Validity criteria and results are stated in the following table:
Table 9.4 -a:
Validity CriterionDemanded Found
Mean OD of negative control > 0.8 and < 2.8 1.8
% mean relative viability of
positive control < 50% of negative control 44.0%
Variation within replicates < 20% 6.6% (negative control)
4.5% (positive control)
4.7% (test item)
Values for negative control and for positive control were within the range of historical data of the test facility.
Therefore, the experiment was considered valid.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The studies in skin irritation in various nanoforms of Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) showed no evidence of erythema or edema. Therefore, there is no need for classification.
Concerning the studies in eye irritation, no adverse effects were observed which would lead to classification according to GHS, no hazard was identified and classification is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.