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Diss Factsheets
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EC number: 210-478-4 | CAS number: 616-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Dimethylcarbonate is a small, highly water soluble molecule with an octanol-water partition coefficient of 0.354. It is likely to be easily absorbed into the body through the skin. However there was no evidence of significant local or systemic toxic effects related to the test substance in any of the animal studies carried out.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Toxicokinetic Assessment
Dimethyl carbonate is a small molecule (molecular weight less than 100 g/mol) which is highly water soluble and has a partition coefficient of 0.354. As such it is likely to be absorbed into the body by the dermal route of exposure. The compound has a moderate vapour pressure of 7.57 KPa at 25 °C and a boiling point of 90 °C indicating that there will be a moderate amount of vapour available for absorption through inhalation and any vapour would be easily absorbed.
Through the various animal studies available no local or systemic effects were observed (see below for summaries), indicating that the test compound did not accumulate target a particular organ or area of the body.
Absorption
There were no studies specifically designed to investigate the absorption of the test substance.
In the toxicity studies, there was no conclusive evidence to indicate whether dimethyl carbonate was or was not absorbed by dermal or inhalation routes. After a single oral administration of 5000mg/kg DMC, the clinical signs indicative of sedation were observed in rats. Those are probably due to methanol, which is produced by degradation of DMC when present in high concentrations. This hypothesis is supported by the fact that no clinical effect is observed in the repeated oral study nor in the one-generation study, when lower doses were tested.
Distribution
There were no studies specifically designed to investigate the distribution of the test substance.
Metabolism
There were no studies specifically designed to investigate the metabolism of the test substance.
Excretion
There were no studies specifically designed to investigate the excretion of the test substance.
Bioaccumulation
There were no studies specifically designed to investigate the bioaccumulation of the test substance. The logKowwas <3 indicating that dimethyl carbonate has low bioaccumulation potential according to REACH guidance on information requirements and chemical safety assessment point R.7.10.3.4.
Conclusion
No studies were specifically designed to investigate the absorption, the distribution, the metabolism and the excretion of DMC. According to the toxicity studies, there was no indication of inhalatory or dermal absorption, metabolism, excretion or distribution. Signs of sedation after acute oral administration at high concentration were probably due to the conversion of DMC in methanol.
The acute rat oral, dermal and inhalation studies, together with the repeat dose inhalation study, and the one-generation study, indicated no resultant adverse toxicity. Similarly, there was no evidence of skin or eye irritation in rabbits or sensitization potential in guinea pigs.
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