Registration Dossier
Registration Dossier
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EC number: 200-842-0 | CAS number: 75-12-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There is no structural alert or mechanism causing skin sensitisation that would indicate a sensitisation potential for formamide in a validated QSAR model, the OECD Toolbox. Negative findings in Guinea pigs and rats support this. Negative results exist for related substances (acetamid, N, N-dimethyl formamide) identified by the QSAR model.
Formamide is therefore not considered to be a skin sensitizer. This endpoint may therefore be waived in accordance with Annex XI, No. 1.3
Migrated from Short description of key information:
There is no structural alert or mechanism causing skin sensitisation that would indicate a sensitisation potential for formamide in a validated QSAR model, the OECD Toolbox. Negative findings in Guinea pigs and rats support this. Negative results exist for related substances (acetamid, N, N-dimethyl formamide) identified by the QSAR model.
Justification for classification or non-classification
Skin sensitisation: no classification because formamide is not considered to be a skin sensitizer, based on the results obtained in a valid QSAR model, and negative results reported from supporting Guinea pig studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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