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EC number: 402-130-7 | CAS number: 106246-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.02 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 44.5 h
- Temp.:
- 20 °C
- pH:
- 8.5
- Conclusions:
- The water solubility was determined to be approx. 0.02 mg/L at 20°C and pH 8.5.
- Executive summary:
The study was performed 1987 as GLP-test following EU-testing method A.6. A preliminary test for solubility was carried out as a range finding test prior to performance of the flask method or the column elution method. Based on the pretest results, the solubility of P5367 in water was determined using the column elution method to prepare a saturated solution. The temperature during the column elution method varied between 20.0°C and 20.5°C. A solid phase extraction method was used to concentrate the resulting solutions. Analyses were performed using High Performance Liquid Chromatography (HPLC). The solubility of P5367 in water was found to be 2.0 x 10 Exp.-5 g/l at 20°C and a pH-value of 8.5. A separate study conducted by another lab gave a result of 0.025 mg/l at 20°C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.025 mg/L
- Incubation duration:
- 48 h
- Temp.:
- 20 °C
- pH:
- ca. 5.8
- Conclusions:
- The water solubility was determined to be approx. 0.025 mg/L at 20°C and pH 5.8.
- Executive summary:
The study was performed as GLP-test following EU-testing method A.6 using the flask method. The solubility of P5367 in water was found to be 2.5 x 10 Exp.-5 g/l at 20°C and a pH-value of approx. 5.8.
Referenceopen allclose all
A preliminary test for solubility was carried out as a range finding test prior to performance of the flask method or the column elution method. Based on the pretest results, the solubility of P5367 in water was determined using the column elution method to prepare a saturated solution. The temperature during the column elution method varied between 20.0°C and 20.5°C. A solid phase extraction method was used to concentrate the resulting solutions. Analyses were performed using High Performance Liquid Chromatography (HPLC). The water solubility was calculated to be 2.0 x 10 E-5 g/1.
Description of key information
The water solubility was measured at two different test laboratories. In both labs, the studies were both performed under GLP and in accordance with EU-testing method A.6, showing almost similar results. The value of 0.02 mg/L (20°C) of the key study was used for the safety assessment.
Key value for chemical safety assessment
- Water solubility:
- 0.02 mg/L
- at the temperature of:
- 20 °C
Additional information
Reference: GLP-report
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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