Registration Dossier
Registration Dossier
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EC number: 202-409-1 | CAS number: 95-31-8
Carcinogenicity
Administrative data
Description of key information
No Carcinogenicity study available.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
Additional information
No carcinogenicity study is available.
No evidence of pre-neoplastic lesions was found in a subchronic gavage study with male and female Sprague-Dawley rats (Monsanto Co 1985). There was no evidence of any gross pathological and histopathological findings associated to dosing with the test substance up to the highest dose group evaluated.
Moreover, the test substance TBBS was shown to be not genotoxic in an in vivo micronucleus assay (Durward 2002)
Overall it can be concluded that there is no evidence to anticipate a carcinogenic potential of TBBS based on the absence of a genotoxic potential in vivo and no observation of pre-neoplastic lesions in an oral repeated dose toxicity study.
The metabolite 2-Mercaptobenzothiazole (MBT) is the relevant and common metabolite for all category members (CBS, TBBS, MDS and DCBS), data on 2-Mercaptobenzothiazole (MBT) CAS No. 149-30-4, EC no. 205-736-8 are also relevant for consideration of the carcinogenic potential of the category of substances. Refer to section 13.2 for the statement of carcinogenic potential of 2-Mercaptobenzothiazole (MBT) for more information.
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