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EC number: 203-867-5 | CAS number: 111-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study. Irreversible skin damage was observed following 4-hr exposure in 2/2 animals, therefore the short observation period (8 days) is in line with the provisions of OECD TG 404.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no 72 h reading
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-aminoethylamino)ethanol
- EC Number:
- 203-867-5
- EC Name:
- 2-(2-aminoethylamino)ethanol
- Cas Number:
- 111-41-1
- Molecular formula:
- C4H12N2O
- IUPAC Name:
- 2-[(2-aminoethyl)amino]ethan-1-ol
- Details on test material:
- AEEA (substance 77/715), degree of purity 99 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M. GAUCKLER, 6050 Offenbach, Germany
- Weight at study initiation: mean bw was 3.0 kg
- Diet: Ssniff K standard diet, Intermast GmbH Soest, Germany, ad libitum:
- Water: tap water ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied : 0.5 mL of the neat test substance was applied to the intact dorsal skin, clipped 24 h before treatment
- Concentration: undiluted - Duration of treatment / exposure:
- 1 hour (4 animals), 4 hours (2 animals)
- Observation period:
- 8 days
- Number of animals:
- 6 male and female rabbits
- Details on study design:
- TEST SITE
- Area of exposure: 4 cm²
- coverage: 100 %
- Type of wrap if used: rubberbacked linen cloth
REMOVAL OF TEST SUBSTANCE
- Washing: At the end of the exposure period excess AEEA was removed and the skin was rinsed with lutrol or a mixiture of water/lutrol (1:1) and dried with pulp
- Skin reactions were examined and scored immediately after patch removal, and 1, 2, and 8 days thereafter
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #1
- Time point:
- other: 4, 24, 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- necrosis developed after 4 hours and was not reversible within 8 days
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #2
- Time point:
- other: 4, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- necrosis developed after 8 days
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24, 48 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- necrosis develpoed in both animals
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #1
- Time point:
- other: 4, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (4 h exposure)
- Basis:
- animal #2
- Time point:
- other: 4, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (4 h exposure)
- Basis:
- mean
- Time point:
- other: 4, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48 hours
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- necrosis developed within 1 day
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #2
- Time point:
- other: 1, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #3
- Time point:
- other: 1, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days, scales developed within 8 days
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #4
- Time point:
- other: 1, 24, 48 hours
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Remarks:
- (1 h exposure)
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours
- Score:
- 2.09
- Max. score:
- 4
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #2
- Time point:
- other: 1, 24, 48 hours
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #3
- Time point:
- other: 1, 24, 48 hours
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (1 h exposure)
- Basis:
- animal #4
- Time point:
- other: 1, 24, 48 hours
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Remarks:
- (1 h exposure)
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours
- Score:
- 1.33
- Max. score:
- 4
- Remarks on result:
- other: 1 h exposure
Any other information on results incl. tables
Necroses (full thickness) were confirmed by pathological
examination of the skin after terminal sacrifice.
No signs of systemic toxicity were noted following either
treatment.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Executive summary:
In a dermal irritation study (BASF AG, Department of Toxicology, 1979) six Vienna White rabbits were dermally exposed to undiluted AEEA. The test site (intact dorsal skin) was covered with an occlusive dressing for 1 or 4 hours. Rabbits then were observed for 8 days. Irritations regarding erythema, edema and necrosis were scored and converted into the presently used numerical grading system according to the OECD system. AEEA exhibited a corrosive potential in this study, since the development of necrosis, which were not reversible within 8 days, were noted in both the 1-hour exposure group (1/4 animals) and the 4-hours exposure group (1/2 animals).
Mean scores 1-hour exposure (4 animals):
Erythema: 2.09 of max. 4
Edema: 1.33 of max. 4
Mean scores 4-hour exposure (2 animals):
Erythema: 3.00 of max. 4
Edema: 2.00 of max. 4
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