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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-01-09 to 1985-04-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conduction and documentation of study very acceptable. Study report available.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- publication
- Title:
- The acute toxicity and primary irri-tancy of 2,4-pentanedione
- Author:
- Ballantyne, B., Dodd, D.E., Myers R.C., Nachreiner, D.J.
- Year:
- 1 986
- Bibliographic source:
- Drug and Chemical Toxicology, 9, 133-146
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as reported in test report
- Deviations:
- no
- Principles of method if other than guideline:
- undiluted TS applied on the shaved dorsal skin (25 cm2) of 3-5 male or female New Zealand White rabbits/group; occlusive contact for 24 h; 14 d post application period; 5 doses tested.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Details on test material:
- - Name of test material (as cited in study report): 2,4-Pentanedione
- Substance type: industrial chemical
- Physical state: liquid
- Analytical purity: > 99%
- Impurities (identity and concentrations): not reported
- Lot/batch No.: 496500
- Expiration date of the lot/batch: not given
- Stability under test conditions: stable
- Storage condition of test material: not given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 to 3.0 kg
- Fasting period before study: no
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 25 cm2
REMOVAL OF TEST SUBSTANCE
- Washing (if done): removal of excess fluid
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2, 1 and 0.5 ml/kg bw
- Constant volume or concentration used: yes
VEHICLE not used - Duration of exposure:
- 24 h
- Doses:
- 2, 1 and 0.5 ml/kg bw
- No. of animals per sex per dose:
- 5 per sex and does
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: one hour, 7 and 14 days after application
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Moving average method of Thompson
Results and discussion
- Preliminary study:
- not reported
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 790 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 560 - 980
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 370 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 770 - 2 100
- Mortality:
- death occurred within 1-24 h after application;
- Clinical signs:
- other: signs of toxicity at 970 mg/kg or more: dilated pupils, salivation and convulsions (high dose); local erythema, edema and necrosis (persisted for 1-7 d) and scab formation at day 14;
- Gross pathology:
- dead animals showed red mottled lungs, patchy congestion of tracheal mucosa, and a few stomachs with superficial black foci at necropsy.
- Other findings:
- - Organ weights: not affected by study
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is harmful in contact with skin under the conditions used.
- Executive summary:
Acetylacetone (2,4 -Pentanedione) was administered to groups of 5 male and 5 female New Zealand White Rabbits. The rabbits received the test material (1.41 and 0.812 ml/kg bw respectively) by retaining the material under impervious sheeting on the clipped intact skin of the trunk.
The LD50 for male rabbits receiving 2,4 -Pentanedione were 790 mg/kg bw for males and 1370 mg/kg bw for females. Erythema,. edema and a few instances of necrosis and scab formation were observed at the dose sites. Signas of toxicity included dilated pupils, bloody discharge from the mouth, salviation abd in one animal convulsions. Time to death ranged from 45 min to one day. Gross pathologic examination revealed mottled and red lungs, a few tracheas with red patches and a few stomache with black foci on the surface. The test substance is harmful in contact with skin under the conditions used.
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