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EC number: 214-685-0 | CAS number: 1185-55-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-06-08 to 2007-06-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Mortality at the intermediate concentrations may be related to the physical mixture of the solvent and test article.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: Measurement of test concentrations in one replicate test chamber of each treatment group at test initiation and test termination.
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test solutions were prepared by direct addition of the test article to dilution water (100 and 200 mg/L treatment groups) or by addition of stocks prepared in DMF (13, 25 and 50 mg/L treatment groups). The solvent solutions were used in the lower concentration treatments in order to facilitate accurate delivery of smaller amounts of the tests substance in the diluter system. The solvent control, 13, 25 and 50 mg/L treatment groups contained 0.1 mL/L DMF. No solvent was delivered in the 100 and 200 mg/L treatment groups. The diluter flow rate provided 32 volume additions/day. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source, supplier, any pretreatment, breeding method: Dow Corning in-house Cultures. The cultures were initiated with organisms obtained from Aquatic Biosystems Inc., Fort Collins, Colorado.
- Age at study initiation: <24 hours old - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Hardness 105 mg/L as CaCO3, Alkalinity 65 mg/L as CaCO3
- Test temperature:
- 19.5 to 21.0ºC
- pH:
- 7.5-7.8
- Dissolved oxygen:
- 7.8-8.9 mg/L
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: Negative Control, Solvent Control, 13, 25, 50, 100 and 200 mg/L
Mean measured concentrations:
Recoveries of methyltrimethoxysilane were low because the hydrolysis half-life is approximately 2.2 hours.
The results are reported with reference to mean measured concentrations. - Details on test conditions:
- TEST SYSTEM
- Exposure vessel type: The test compartments were 300-mL glass beakers with 2 holes on opposite sides covered with nylon screen. The test chambers were placed in 7.5-L polyethylene aquaria containing 3.4 L of test solution.
- Dilution water source: Dechlorinated Municipal Water
- Dilution water chemistry (hardness, alkalinity, pH, TOC, TSS, salinity, Ca/Mg ration, Na/K ratio): Hardness 105 mg/L as CaCO3, Alkalinity 65 mg/L as CaCO3, pH 7.6, Conductivity 319 mhos/cm and Total Residual Chlorine <10 g/L
- Lighting (quality, intensity, and periodicity): Wavelength similar to natural sunlight, 55 to 66 foot-candles, 16 hours light:8 hours dark
- Water chemistry in test: DO, pH and temperature measured in each test chamber daily
- Element (unit) basis (i.e., immobilization): Mortality and immobilization
- Test design (number of replicates, individuals per replicate, concentrations): Two replicates/treatment, 10 individuals/replicate
- Method of calculating mean measured concentrations: Arithmetic mean. - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 122 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 122 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Immobilisation of control: 0
- Reported statistics and error estimates:
- No significant mortalities were recorded in the highest treatment. An EC50 value could therefore not be determined.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-hour EC50 value of >122 mg/L and NOEC of ≥122 mg/L have been determined for the effects of the substance on mobility of Daphnia magna. Under the flow-through conditions used in the test the results reflect exposure to the test substance.
Reference
Table 1. Test results
Nominal concentration (mg/L) | Mean measured concentration (mg/L) | Percentage immobilisation after 24 hours | Percentage immobilisation after 48 hours |
0 (Control) | - | 0 | 0 |
0 (Vehicle control) | - | 0 | 0 |
13 | 6 | 0 | 0 |
25 | 15 | 0 | 35 |
50 | 31 | 0 | 75 |
100 | 56 | 0 | 0 |
200 | 122 | 0 | 0 |
Was control response satisfactory: Yes
The effects observed in the 15 and 31 mg/L treatments were thought to relate to physical interaction with the test substance and solvent.
Description of key information
Short-term toxicity to aquatic invertebrates: 48-hour EC50 >122 mg/l (measured concentration), mobility of Daphnia magna.
Key value for chemical safety assessment
Additional information
A 48-hour EC50 value of >200 mg/l, based on nominal concentration (highest concentration tested), and >122 mg/l, based on measured concentration, has been determined for the effects of the registered substance on mobility of Daphnia magna (Dow Corning Corporation 2007). The test was carried out in accordance with test guideline OECD 202 and in compliance with GLP. Under the flow-through conditions used in the test it is likely that the Daphnia were exposed to a mixture of the parent substance and its hydrolysis products. This is reflected in the nominal versus measured test concentrations.
To support the chemical safety assessment of the hydrolysis product, methylsilanetriol (CAS 2445-53-6; EC No. 219-489-9), data have been read-across from a structural analogue which rapidly hydrolyses to methylsilanetriol. A 96-hour EC50 value of >500 mg/l (nominal concentration) (highest concentration tested) has been determined for the effects of triethoxy(methyl)silane (CAS 2031-67-6; EC No. 217-983-9) on mobility of Daphnia magna (Hazelton, 1994), carried out in accordance with EU test Method C.3 and in compliance with GLP.
In view of the test media preparation method/exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. The results may be expressed in terms of concentration of the hydrolysis product, methylsilanetriol, by applying a molecular weight correction: (MW of silanol = 94.14 / MW of parent = 178.31) * (CONCENTRATION OF PARENT = >500) = >264 mg/l as methylsilanetriol.
Refer to Section 6 endpoint summary, Section 7.0 of CSR, for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
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