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Diss Factsheets
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EC number: 260-754-3 | CAS number: 57472-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
There are valid in vivo data available for the assessment of the skin sensitization potential of DPGDA.
A Local Lymph Node Assay (LLNA) was conducted in mice, according to OECD guideline 406 (Central Toxicology Laboratory 2000, Val. 1). The application of the test substance at concentrations of 3%, 10% and 30% w/v in acetone resulted in an increase in isotope incorporation which was greater than 3-fold at all concentrations (0 % vehicle only: 3431 dpm; 3 %: 67078 dpm; 10 %: 62324 dpm; 30 % 60335 dpm). Consequently, the test substance was shown to be a potential skin sensitiser. Following the third application, the ears of animals dosed with 10% and 30% w/v preparations were red and, for the following 3 days, the ears were also swollen and sensitive to touch. The ears of animals dosed with the 3% w/v preparation were red on the day following the third application.
For the sensitising potential of the test substance, a qualitative assessment was conducted:
The derivation of an EC3 was not possible. The available LLNA data indicates that the EC3 is definitely below 3 %. However, taking into account the observed irritating effects on the ears, and the missing dose-dependency of the lymph node proliferation, the sensitising effect cannot be clearly discriminated from at least partly possible lymph node proliferation based on skin irritancy.
If taking into account data from similar substances, it can be excluded that the test substance is an strong or extreme sensitiser.It can therefore be concluded that the test substance is a moderate sensitiser.
Migrated from Short description of key information:
Mouse, LLNA: sensitizing (acc. OECD 406, Central Toxicology Laboratory 2000, Val. 1)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No information is available
Migrated from Short description of key information:
No information is available
Justification for classification or non-classification
In the LLNA, Laromer DPGDA was demonstrated to be a skin sensitizer.
The substance will therefore be classified as sensitizing (Category 1) according to GHS criteria.
There are no data available to classify DPGDA as a sensitizer of the respiratory tract.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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