Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-059-3 | CAS number: 3332-27-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available for C14 AO. A study is available for C12-14 AO in which the rate of hydrolysis was investigated for both the C12 and C14 homologues. Although the results for C14 AO from this study were inconsistent, the results from C12 AO may be read across to C14 AO as any potential for hydrolysis will not be affected by the difference in alkyl chain length between the two substances. Based on the results of the OECD 111 study performed on the homologues of C12-14 AO, C14 AO is stable to hydrolysis at room temperature.
Key value for chemical safety assessment
Additional information
No studies are available for C14 AO. A study is available for C12-14 AO in which the rate of hydrolysis was investigated for both the C12 and C14 homologues. Although the results for C14 AO from this study were inconsistent, the results from C12 AO may be read across to C14 AO as any potential for hydrolysis will not be affected by the difference in alkyl chain length between the two substances.
Hydrolysis of C12-C14 alkyl dimethylamine oxide (AO) was investigated at pH 4, 7 and 9 according to OECD Test Guideline 111 and EU Method C.7 [Analytico Medinet B. V. (2002) ]. AO was tested at a nominal concentration of 4167 µg/L for 5 days at 50 °C.
Both the C12 and C14 homologues of the test substance were evaluated. Analytical samples were taken at time 0 and after 5 days of incubation at 50 °C and protected from light to prevent photolysis. Samples were analysed by atmospheric pressure ionization interfaced with flow injection/mass spectrometry (FI-MS/MS). Internal calibration standards were prepared from deuterated test substance. Results of the test solutions at pH 4, 7 and 9 showed no significant decrease of concentration after 5 days of incubation at 50 °C for the C12 homologue. For the C14 homologue, the same results were obtained at pH 7 and 9. However, at pH 4 a significant decrease of concentration of 27.5% was observed. Re-analysis of the extracts confirmed these results. No explanation could be found for this possible hydrolysis of the C14 homologue at pH 4, especially because the C12 homologue didn't show any significant decrease of concentration at pH 4. Therefore, the 5-day test at pH 4 was repeated. In the repeat test, the C12 homologue showed similar results to the initial test. However, the duplicate of the repeated test for the C14 homologue showed inconsistent results. One test solution showed a decrease of 44.3% and the duplicate showed a decrease of 5.6%. Results of the C14 homologue showed that the analytical method used for the determination of the C14 homologue was not consistent. As a result, conclusions were based on the C12 homologue results only.
The test solutions at pH 4, 7 and 9 showed no significant decrease in concentration of the C12 homologue after 5 days of incubation. Further testing at these pH levels was not required according to the EEC Directive 92/69 EEC Annex V, Part C.7 criteria; therefore, it can be stated that the test substance is hydrolytically stable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.