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EC number: 295-835-2 | CAS number: 92129-33-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1988-03-16 to 1988-03-0-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides
- EC Number:
- 263-090-2
- EC Name:
- Quaternary ammonium compounds, bis(hydrogenated tallow alkyl)dimethyl, chlorides
- Cas Number:
- 61789-80-8
- IUPAC Name:
- 61789-80-8
- Reference substance name:
- dihydrogenatedtallowdimethylammonium chloride
- IUPAC Name:
- dihydrogenatedtallowdimethylammonium chloride
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River France
- Age at study initiation: approximately 9 weeks
- Weight at study initiation: males: 281 +/- 5 g; females: 221 +/- 6 g
- Fasting period before study: no
- Housing: polypropylene cages (one animal per cage)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 50 +/- 20%
- Air changes (per hr): 12 per hour
- Photoperiod (hrs dark / hrs light): 12 hours periodically
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5 x 7 cm
- % coverage: approximately 10% of body surface
- Type of wrap if used: gauze patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg body weight
- Concentration (if solution): n.a.
- Constant volume or concentration used: n.a.
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): water
- Concentration (if solution): n.a.
- Lot/batch no. (if required): n.a.
- Purity: n.a. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight (limit dose)
- No. of animals per sex per dose:
- 5 male; 5 female
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- n.a.
Results and discussion
- Preliminary study:
- n.a.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality througout study period
- Clinical signs:
- other: no clinical signs throughout study period
- Gross pathology:
- no abnormalities
- Other findings:
- - Organ weights: no data
- Histopathology: not performed
- Potential target organs: no target identified
- Other observations: none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (Reg. 1272/2008/EC) and Directive 67/548/EEC
- Conclusions:
- The LD50 of the test material was greater 2000 mg/kg body weight in rats. According to the criteria laid down in CLP (Reg 1272/2008/EC) and directive 67/548/EEC, the test material is not classified for acute dermal toxicity.
- Executive summary:
The acute dermal toxicity of the test material (dihydrogenated tallowalkyldimethyl ammonium chloride, purity approximately 97%) was investigated in rats according to OECD Test Guideline 402 in compliance with the principles of GLP. The test substance was applied as an aqueous suspension to the shaved skin of 5 male and 5 female animals at a dose level of 2000 mg/kg body weight (limit dose) under occlusive conditions. Mortality, general behaviour, clinical signs and body weight development were recorded daily for an observation period of 14 days. A necropsy was performed on each animal sacrificed at the end of the study. There was no mortality throughout the study period at the dose level of 2000 mg/kg body weight. General behaviour and bodyweight of the animals were not influenced by the treatment. Clinical signs of significance were not observed. Skin dryness was noted after the removal of the dressing up to day 6 in all animals. Additional signs of skin irritation were not observed. The macroscopic examination of the main organs did not reveal abnormalities in any of the animals sacrificed at the end of the observation period. Based on the study results, the median lethal dose (LD50) of the test material when administered dermally to rats is greater than 2000 mg/kg body weight. Additionally, at this dose level the test material did not induce any signs of toxicity.
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