Registration Dossier
Registration Dossier
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EC number: 208-208-5 | CAS number: 515-74-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to OECD 107, but 1 of 6 measurements not included in calculation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sodium sulphanilate
- EC Number:
- 208-208-5
- EC Name:
- Sodium sulphanilate
- Cas Number:
- 515-74-2
- Molecular formula:
- C6H7NO3S.Na
- IUPAC Name:
- sodium 4-aminobenzenesulfonate
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -3.93
- Temp.:
- 23 °C
- pH:
- ca. 7
- Remarks on result:
- other: mean of 5 measurements
Any other information on results incl. tables
Table 1: Results
no. |
stock solution [mL] |
n-octanol [mL] |
conc. in water phase [mg/L] |
conc. in n-octanol phase [mg/L] |
Log pow |
A1 |
5 |
10 |
1842,5 |
1,49 |
-3,09* |
A2 |
5 |
10 |
1782,1 |
0,20 |
-3,96 |
B1 |
10 |
10 |
1847,9 |
0,19 |
-3,99 |
B2 |
10 |
10 |
1854,4 |
0,21 |
-3,95 |
C1 |
20 |
10 |
1766,0 |
0,20 |
-3,95 |
C2 |
20 |
10 |
1735,4 |
0,29 |
-3,77 |
mean |
- |
- |
- |
- |
-3,93 |
*outlier, not used in calculation
Stock solution: 630 mg/L
Applicant's summary and conclusion
- Conclusions:
- Result log pow = -3.93 (mean of 5 measurements).
- Executive summary:
The partition coefficient (log pow) of the test substance sodium sulphanilate was determined according to OECD Guideline 107.
Result log pow = -3.93 (mean of 5 measurements).
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