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EC number: 206-696-4 | CAS number: 367-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals
- Author:
- Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K and Speck W
- Year:
- 1 987
- Bibliographic source:
- Environ Mutagen, 9(suppl.9), 1-109
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium mercaptoacetate
- EC Number:
- 206-696-4
- EC Name:
- Sodium mercaptoacetate
- Cas Number:
- 367-51-1
- Molecular formula:
- C2H4O2S.Na
- IUPAC Name:
- sodium sulfanylacetate
- Details on test material:
- Test compound: sodium thioglycolate
CAS no.: 367-51-1
Source: Matheson Coleman. Bell
Batch: no data
Purity: no data
Constituent 1
Method
- Target gene:
- Histidine reversion
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: Strains: TA98, TA100, TA1535 and TA1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat and hamster liver S9 induced with aroclor 1254
- Test concentrations with justification for top dose:
- 0, 10, 33, 100, 333 and 1000 µg/plate
- Vehicle / solvent:
- no data
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: Without activation : sodium azide (TA1535 and TA 100), 9-aminoacridine (TA 97), 4-nitro-o-phenylenediamine (TA98). With activation : 2-aminoanthracene (all strains).
- Details on test system and experimental conditions:
- In the Salmonella assay, a test tube containing a suspension of one strain of Salmonella typhimurium plus S9 mix or plain buffer without S9, is incubated for 20 minutes at 37º C with the test chemical. Control cultures, with all the same ingredients except the test chemical, are also incubated. In addition, positive control cultures are also prepared; these contain the particular bacterial tester strain under investigation, the various culture ingredients, and a known potent mutagen. After 20 minutes, agar is added to the cultures and the contents of the tubes are thoroughly mixed and poured onto the surface of Petri dishes containing standard bacterial culture medium. The plates are incubated for 48 hours and then counted. The substance was tested initially in a toxicity assay to determine the appropriate dose range.
The toxicity assay was performed by using TA 100. Toxic concentrations were those at which a decrease in the number of his+ colonies was seen or at which there was a clearing in the density of the background lawn.
- Test Design . Number of replicates : 3
- Description of follow up repeat study : same conditions than the initial experiment performed 1 week later - Evaluation criteria:
- The positive control plates are counted, and the number of mutant colonies appearing on them must be significantly increased over the spontaneous control number for the test to be considered valid. If no increase in mutant colonies is seen after testing several strains under several different culture conditions, the test chemical is considered to be non mutagenic in the Salmonella test.
- Statistics:
- None
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: Strains: TA98, TA100, TA1535 and TA1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- > 1000 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Chemical Name: |
Sodium thioglycolate |
CAS Number: |
367-51-1 |
Study Type: |
Salmonella |
Study ID: |
471613 |
Study Result: |
Negative |
Year Completed: |
1979 |
Vehicle Control: |
Water |
Protocol: |
Preincubation |
Individual strain data is presented as mean ± standard error. |
Abbreviations are noted at bottom of page. |
Trial summary calls are shown in parentheses. |
Strain: TA1535 |
|||||||||||
Dose |
No Activation |
No Activation |
10% HLI |
10% HLI |
10% RLI |
||||||
(Negative) |
(Negative) |
(Negative) |
(Negative) |
(Negative) |
|||||||
ug/Plate |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
|
0 |
7 |
0.7 |
7 |
0.6 |
6 |
0.9 |
7 |
2.6 |
7 |
0.7 |
|
10 |
6 |
1 |
6 |
0.9 |
5 |
0.9 |
6 |
2 |
8 |
1.2 |
|
33 |
5 |
1.5 |
6 |
0.9 |
7 |
1.5 |
9 |
1.2 |
6 |
1.3 |
|
100 |
8 |
3.5 |
9 |
1.3 |
7 |
0.6 |
9 |
0.7 |
6 |
0.9 |
|
333 |
6 |
0.6 |
6 |
0.9 |
5 |
1.2 |
7 |
1.5 |
8 |
1.2 |
|
1000 |
5 |
1.2 |
8 |
2 |
5 |
0.3 |
8 |
1.2 |
8 |
0.9 |
|
Positive Control |
288 |
32.3 |
251 |
40.8 |
106 |
16 |
43 |
4.1 |
135 |
9.7 |
Strain: TA100 |
|||||||||||||
Dose |
No Activation |
No Activation |
10% HLI |
10% HLI |
10% RLI |
10% RLI |
|||||||
(Negative) |
(Negative) |
(Negative) |
(Equivocal) |
(Negative) |
(Negative) |
||||||||
ug/Plate |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
|
0 |
100 |
5 |
110 |
5.8 |
185 |
26.5 |
179 |
11.7 |
175 |
27.8 |
189 |
8.7 |
|
10 |
95 |
5 |
126 |
11.4 |
160 |
18 |
164 |
6.2 |
140 |
30.4 |
204 |
37.7 |
|
33 |
105 |
31.2 |
129 |
7.5 |
195 |
30 |
174 |
7.6 |
170 |
40.9 |
189 |
3.5 |
|
100 |
115 |
10 |
121 |
3.8 |
220 |
18 |
221 |
4.2 |
145 |
18 |
175 |
9 |
|
333 |
125 |
13.2 |
122 |
8.5 |
160 |
5 |
173 |
10.1 |
135 |
8.7 |
221 |
8.1 |
|
1000 |
120 |
30 |
124 |
8.8 |
215 |
13.2 |
202 |
4.3 |
155 |
35 |
181 |
18.1 |
|
Positive Control |
430 |
27.8 |
599 |
36.4 |
558 |
5.9 |
836 |
172.5 |
300 |
11.1 |
430 |
70.3 |
Applicant's summary and conclusion
- Conclusions:
- Under these experimental conditions, sodium thioglycolate is considered as non-genotoxic
- Executive summary:
In a study performed according to the US NTP protocol, four S. typhimurium strains (TA 98, TA 100, TA 1535 and TA 1537) were exposed to sodium thioglycolate in a preincubation assay. Based on a preliminary toxicity assay, concentrations up to 1000 µg/plate were used with or without metabolic activation (rat and hamster S9) in all four strains. Sodium thioglycolate did not induce mutations in these studies. Positive and solvent controls gave the expected results.
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