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Diss Factsheets
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EC number: 227-561-6 | CAS number: 5888-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
1) The extended OECD 301F (GLP, 2021) showed a degradation of 73.9 % after 60 days without reaching a plateau phase. Following the Integrated assessment and testing of Persistence (ECHA Guidance Document R.11) these information are sufficient to conclude, that IBoA is not persistent (not P/ not vP).
2 and 3) Further, the results show an extensive biodegradability of IBoA, even though the criteria for 'readily biodegradability' are not met, due to not meeting the 10-day-window criteria. The label 'inherently biodegradable' is used for the exposure assessment calculations and which indicate no risk to aquatic organisms. As the emblem 'inherently biodegradable' is also given to substances with a degradation plateau slightly over 20 % after 28 days with no further degradation, the more than inherent biodegradability of IBoA suggests that the margin of safety calculated in the exposure assessment is conservative and protective for aquatic organisms.
4) Additionally, ester hydrolysis by carboxylesterases has been established as the primary step in the metabolism of esters of simple carboxyl acids like acryl acid. For IBoA, this hydrolytic step leads to the rapid degradation into Isoborneol (IBo, EC-No. 204-712-4) and Acrylic Acid (AA, EC-No. 201-177-9). The rapid metabolism of IBoA was shown in rats in a metabolism study with 1 % of the corresponding intravenous administered dose remaining in the blood after 10 min (DOW, 2019; see section metabolism). As carboxylesterases are documented for all major organism groups i.a. fish, mammals, plants, fungi and microorganisms, this metabolism pathway can be expected to be the major degradation pathway in the environment and in organisms.
5) The primary degradation products IBo and AA are both readily biodegradable in water fulfilling the 10-day-window criteria (biodegradation screening studies) and have a logKow < 3. Therefore, a bioaccumulation within the organism or an accumulation in the environment can be neglected for the primary metabolites of IBoA.
Data source
Materials and methods
Results and discussion
- Transformation products:
- not measured
- Remarks:
- The hydrolysis of IBoA into its primary metabolites Isoborneol (IBO, EC-No. 204-712-4) and Acrylic Acid (AA, EC-No. 201-177-9) via carboxylesterases has been established. Please see the remark below for further information.
Identity of transformation productsopen allclose all
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- prop-2-enoic acid
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 201-177-9]
- CAS number:
- 79-10-7
- Molecular formula:
- C3H4O2
- Molecular weight:
- 72.063
- SMILES notation:
- OC(=O)C=C
- InChl:
- InChI=1/C3H4O2/c1-2-3(4)5/h2H,1H2,(H,4,5)
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 204-712-4]
- CAS number:
- 124-76-5
- Molecular formula:
- C10H18O
- Molecular weight:
- 154.249
- SMILES notation:
- C[C@@]12CC[C@@H](C[C@@H]1O)C2(C)C
- InChl:
- InChI=1/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3
- Details on transformation products:
- - Ester hydrolysis by carboxylesterases has been established as the primary step in the metabolism of esters of simple carboxyl acids like acryl acid - including IBoA. For IBoA, this hydrolytic step leads to the degradation into Isoborneol (IBO, EC-No. 204-712-4) and Acrylic Acid (AA, EC-No. 201-177-9). The rapid metabolism of IBoA was shown in rats in a metabolism study with 1 % of the corresponding intravenous administered dose remaining in the blood after 10 min (DOW, 2019; see section metabolism). As carboxylesterases are documented for all major organism groups i.a. fish, mammals, plants, fungi and microorganisms, this metabolism pathway can be expected to be the corresponding major degradation pathway in the environment. IBO and AA are both readily biodegradable in water, fulfilling the 10-window criteria (biodegradation screening studies).
- The primary metabolites IBO and AA have a log Kow < 3 and are readily biodegradable (both meeting the 10-day-window criteria). Therefore, a bioaccumulation within the organism or an accumulation in the environment can also be neglected for the primary metabolites of IBoA.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.