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Diss Factsheets
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EC number: 202-876-1 | CAS number: 100-66-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Lack of information regarding test conditions, and specially for concentrations and open or closed system.
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- not applicable
- Principles of method if other than guideline:
- other: DIN L15 Fischtest "Bestimmung der Wirkung von Wasserinhaltsstoffen auf Fische"
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Leuciscus idus melanotus
- Details on test organisms:
- Test fish :
- Age : Information not available.
- Length : 5-7 cm.
- Weight : 1.5+/-0.3 g.
- Loading : 1.5+/-0.3 g/litre of test solution.
- Pretreatment : Information not available. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 15+/-3°d
- pH:
- 7-8
- Details on test conditions:
- Test conditions :
- Dilution water source : Drinking water.
- Dilution water chemistry : Hardness 15+/-3°d; pH: 7-8 Free from chlorine; Mg, Ca concentration 2.7+/-0.5 mmol/L; Proportion Ca:Mg ions 4:1;
Acid capacity KS 4.3 0.7-0.9 mmol/L; Aeration.
- Stock and test solution and how they are prepared : Information not available.
- Concentrations dosing rate, flow-through rate, in what medium : Test substance was diluted in drinking water. No information available about test
concentrations.
- Vehicle/solvent and concentrations : Information not available.
- Stability of the test chemical solutions : Information not available.
- Exposure vessel type : Aquarium (height: 24 cm; length: 32 cm; depth: 22 cm; volume: 17 L); 10 L of test solution and 10 fish per aquarium; Test solution mixed by aeration. It was not mentioned if the aquariums were closed or not during the test period.
- Number of replicates, fish per replicate : 10 fish per replicate. No information available about number of replicates.
- Water chemistry in test (DO, pH) in the control and one concentration where effects were observed : In test, the O2-concentration of test solution was 5 mg/L. No information available about pH.
- Control group : Information not available
- Test temperature range : 20+/-1°C.
- Method of calculating mean measured concentrations : The EC50-value was evaluated by graphic exploitation. - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 120 - 149 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Nominal concentrations : Information not available.
- Measured concentrations : Information not available.
- Element value : This study reports the results obtained with Leuciscus idus melanotus under comparable conditions in two different laboratories : "Institut für Wasser-, Boden- und Lufthygiene des Bundesgesundheitsamtes Berlin" (JUHNKE I.) and "Landesanstalt für Wasser und Abfall NW" (LÜDEMANN D.).
Results obtained by JUHNKE I. :
LC0 (48 h) = 79 mg/L
LC50 (48 h) = 120 mg/L
LC100 (48 h) = 139 mg/L
Results obtained by LÜDEMANN D. :
LC0 (48 h) = 99 mg/L
LC50 (48 h) = 149 mg/L
LC100 (48 h) = 198 mg/L
- Statistical results : Information not available - Validity criteria fulfilled:
- not specified
- Conclusions:
- Anisole is not harmful to fish.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publication in german. No summary available. Static test.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Test organisms (species):
- Leuciscus idus
- Test type:
- static
- Water media type:
- freshwater
- pH:
- 7.5 +/- 0.3 (adjusted if necessary)
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
No more information.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Anisole is not harmful to fish.
Referenceopen allclose all
Description of key information
LC50 > 100 mg/L
Key value for chemical safety assessment
Additional information
Two data are available for this endpoint. Due to lack of information, these data are scored 3 in the endpoint study summary. However, both studies are consistent in their results, concluding that anisole is not harmful to fish. Therefore, a weight of evidence approach is performed to document this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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