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Diss Factsheets
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EC number: 239-415-9 | CAS number: 15396-00-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.05.2004 to 16.12.2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(trimethoxysilyl)propyl isocyanate
- EC Number:
- 239-415-9
- EC Name:
- 3-(trimethoxysilyl)propyl isocyanate
- Cas Number:
- 15396-00-6
- Molecular formula:
- C7H15NO4Si
- IUPAC Name:
- (3-isocyanatopropyl)trimethoxysilane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, North Carolina
- Age at study initiation: 8-10 weeks old
- Weight at study initiation: Males: 272-298 g; Females: 232-257 g.
- Fasting period before study: No data
- Housing: Individual suspended wire-mesh cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Minimum of 7 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22± 3
- Humidity (%): 50± 20
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 09.09.2004 To: 01.10.2004
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:
- Exposure chamber volume:
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:
- Method of particle size determination:
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:
TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes/no - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 3.9, 11.0 and 17.8 ppm (actual)
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were made following exposure on study day 0 and once daily thereafter for 14 days. Body weights were obtained immediately prior to exposure on study day 0 and on post-exposure days 7 and 14. All animals that died during the study were weighed.
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic examination.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 15 ppm
- Based on:
- test mat.
- 95% CL:
- >= 12 - <= 18
- Exp. duration:
- 4 h
- Mortality:
- Mortality was 0/10, 1/10 and 8/10 animals for the 3.9, 11.0 and 17.8 ppm groups, respectively.
One male in the 11.0 ppm group was found dead on the day following exposure (study day 1). Five males and three females in the 17.8 ppm group were found dead during the study. All deaths were noted within four days of exposure. - Clinical signs:
- other: Clinical observations immediately following exposure included rales in all groups; gasping and laboured respiration in the 11.0 and 17.8 ppm groups; and hypoactivity and hypothermia in the 17.8 ppm group. Significant clinical observations for the survivin
- Body weight:
- Two females in the 3.9 ppm group lost weight during study days 7 and 14 and three males and one female in the 11.0 ppm group lost weight during study days 0 to 7. Both of the surviving females in the 17.8 ppm group lost weight during study days 0 to 7. With the exception of one female in the 3.9 ppm group, all animals surpassed their initial body weight by study day 14 and were considered normal.
- Gross pathology:
- There were no gross findings for the male found dead in the 11.0 ppm group. For the animals found dead in the 17.8 ppm group, the only internal gross findings were lungs not fully collapsed for one male. At the scheduled necropsy, dark red discolouration of the mandibular lymph node was noted for one female each in the 11.0 and 17.8 ppm groups.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- In an acute vapour inhalation study conducted to OECD 403 and to GLP (reliability score 1) the LC50 for a 4-hour exposure to 3-(trimethoxysilyl)propyl isocyanate was 15 ppm (125.95 mg/m3) in rats. Clinical observations immediately following exposure included rales in all groups; gasping and laboured respiration in the 11.0 and 17.8 ppm groups and hypoactivity and hypothermia in the 17.8 ppm group. Significant clinical observations for the surviving animals during the 14-day post-exposure observation period consisted of rales in all groups; decreased defecation/urination, hypothermia and laboured respiration in the 11.0 and 17.8 ppm groups, and gasping and hypoactivity in the 17.8 ppm group. All animals in the 3.9 ppm group were considered normal by study day 2. Surviving animals in the 11.0 and 17.8 ppm groups were considered normal by study days 9 and 7, respectively. There were no gross findings for the male found dead in the 11.0 ppm group. For the animals found dead in the 17.8 ppm group, the only internal gross findings were lungs not fully collapsed for one male. At the scheduled necropsy, dark red discolouration of the mandibular lymph node was noted for one female each in the 11.0 and 17.8 ppm groups.
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