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Diss Factsheets
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EC number: 414-940-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Test article: CGA 224443 tech.
- Batch No.: P.810012
- Purity: 92,6 %
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ciba-Geigy Ltd.
- Age at study initiation: 6 - 8 weeks
- Weight at study initiation: 171 - 221 g
- Housing: Macrolon cages type 4, soft wood bedding
- Diet (e.g. ad libitum): NAFAG 890 Tox, and water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- DESIGN AND PROCEDURE
- Administration of the test article: one single oral dose, by gastric intubation (gavage)
- Dose levels, sex group: 200 mg/kg females; 1000 mg/kg males and females; 2000 mg/kg females
- Total number of animals: 20
- Vehicle: Oil arachidis Ph.H.VI (Siegfried AG, Switzerland)
- Volume applied: 10 ml/kg body weight
- Observation period: 14 days - Doses:
- 200 mg/kg females
1000 mg/kg males and females
2000 mg/kg females - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- OBSERVATIONS AND RECORDS
- Observation period: 14 days
- Mortality: daily; a.m. and p.m. on working days, a.m. on weekend days
- Signs and symptoms: daily
- Body weight: immediately before administration and on days 7 and 14, and at death
- Necropsies: Spontaneously dying animals were submitted to a gross necropsy as soon as possible; survivors at the end of the observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 174 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 273 mg/kg bw
- Mortality:
- see attached Table 1
- Clinical signs:
- Piloerection, hunched posture, exophthalmos and dyspnea were seen, being common symptoms in acute tests.
Additionally, reduced locomotor activity and cyanose was observed in the males dosed with 1000 and 2000 mg/kg, respectively. All females of the 2000 and one female of the 1000 mg/kg experienced ataxia, the former group died two days after administration. In one male dosed with 1000 mg/kg respiratory sounds were recorded, two died within four days after administration.
The surviving animals recoverd within 5 to 7 days.
See attached Table 3 - Body weight:
- see attached Table 2
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.